(S)-2-[(S)-2-((2S,3S)-2-{(S)-2-Benzyloxycarbonylamino-3-[(R)-2-methoxycarbonyl-2-(trityl-amino)-ethylsulfanyl]-propionylamino}-3-methyl-pentanoylamino)-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

Base Information

Chemical Name:(S)-2-[(S)-2-((2S,3S)-2-{(S)-2-Benzyloxycarbonylamino-3-[(R)-2-methoxycarbonyl-2-(trityl-amino)-ethylsulfanyl]-propionylamino}-3-methyl-pentanoylamino)-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid tert-butyl ester
CAS No.:75816-65-8
Molecular Formula:C₆₅H₇₈N₅O₁₃PS
Molecular Weight:1200.4
Hs Code.:

(S)-2-[(S)-2-((2S,3S)-2-{(S)-2-Benzyloxycarbonylamino-3-[(R)-2-methoxycarbonyl-2-(trityl-amino)-ethylsulfanyl]-propionylamino}-3-methyl-pentanoylamino)-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

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Suppliers and Price of (S)-2-[(S)-2-((2S,3S)-2-{(S)-2-Benzyloxycarbonylamino-3-[(R)-2-methoxycarbonyl-2-(trityl-amino)-ethylsulfanyl]-propionylamino}-3-methyl-pentanoylamino)-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

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Chemical Property of (S)-2-[(S)-2-((2S,3S)-2-{(S)-2-Benzyloxycarbonylamino-3-[(R)-2-methoxycarbonyl-2-(trityl-amino)-ethylsulfanyl]-propionylamino}-3-methyl-pentanoylamino)-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

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Technology Process of (S)-2-[(S)-2-((2S,3S)-2-{(S)-2-Benzyloxycarbonylamino-3-[(R)-2-methoxycarbonyl-2-(trityl-amino)-ethylsulfanyl]-propionylamino}-3-methyl-pentanoylamino)-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

There total 7 articles about (S)-2-[(S)-2-((2S,3S)-2-{(S)-2-Benzyloxycarbonylamino-3-[(R)-2-methoxycarbonyl-2-(trityl-amino)-ethylsulfanyl]-propionylamino}-3-methyl-pentanoylamino)-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 75816-38-5,75879-13-9
N^α-benzyloxycarbonyl-D-hemilanthionyl-L-isoleucyl-L-seryl-L-leucine t-butyl ester N^α'-trityl-L-hemilanthionine α'-methyl ester

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 75816-65-8
(S)-2-[(S)-2-((2S,3S)-2-{(S)-2-Benzyloxycarbonylamino-3-[(R)-2-methoxycarbonyl-2-(trityl-amino)-ethylsulfanyl]-propionylamino}-3-methyl-pentanoylamino)-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: In pyridine; at 0 ℃; for 4h;

Reference yield:

: 28252-48-4
Z-Ser-Leu-OBu^t

: 75816-65-8
(S)-2-[(S)-2-((2S,3S)-2-{(S)-2-Benzyloxycarbonylamino-3-[(R)-2-methoxycarbonyl-2-(trityl-amino)-ethylsulfanyl]-propionylamino}-3-methyl-pentanoylamino)-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) hydrogen, 2.) 0.4N-hydrogen chloride / 1.) 10percent palladium-charcoal / 1.) 1percent acetic acid in methanol, 2.5 h, 2.) methanol, -15 deg C

2: 90 percent / triethylamine / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temperature, 1 h

3: 1.) hydrogen, 2.) 0.4N-hydrogene chloride in methanol / 1.) 10percent palladium-charcoal / 1.) 1percent acetic acid in methanol, 2.5 h, 2.) -15 deg C

4: 85 percent / triethylamine / dimethylformamide

5: 76 percent / pyridine / 4 h / 0 °C

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide;

Reference yield:

: 3160-59-6
N-Cbz-L-Isoleucine

: 75816-65-8
(S)-2-[(S)-2-((2S,3S)-2-{(S)-2-Benzyloxycarbonylamino-3-[(R)-2-methoxycarbonyl-2-(trityl-amino)-ethylsulfanyl]-propionylamino}-3-methyl-pentanoylamino)-3-(diphenoxy-phosphoryloxy)-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

2: 90 percent / triethylamine / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temperature, 1 h

3: 1.) hydrogen, 2.) 0.4N-hydrogene chloride in methanol / 1.) 10percent palladium-charcoal / 1.) 1percent acetic acid in methanol, 2.5 h, 2.) -15 deg C

4: 85 percent / triethylamine / dimethylformamide

5: 76 percent / pyridine / 4 h / 0 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide;