(S,R,R)-α-tocopheryl methyl ether

Base Information

• Chemical Name: (S,R,R)-α-tocopheryl methyl ether
• CAS No.: 79434-97-2
• Molecular Formula: C₃₀H₅₂O₂
• Molecular Weight: 444.742
• Mol file: 79434-97-2.mol

Synonyms:

Chemical Property of (S,R,R)-α-tocopheryl methyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S,R,R)-α-tocopheryl methyl ether

There total 2 articles about (S,R,R)-α-tocopheryl methyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C39H55ClO5 (1169860-40-5) + acetic anhydride (108-24-7) + methyl iodide (74-88-4) → (S,R,R)-α-tocopheryl methyl ether (79434-97-2) + (2R,4'R,8'R)-α-tocopheryl methyl ether (32466-45-8)

Guidance literature:

C₃₉H₅₅ClO₅; With lithium aluminium tetrahydride; In tetrahydrofuran; for 18h; Reflux;

acetic anhydride; In pyridine; at 25 ℃; for 4h;

methyl iodide; optical yield given as %ee; Further stages;

DOI:10.1002/ejoc.200900019

Reference yield:

vitamin E (59-02-9,18920-62-2) + dimethyl sulfate (77-78-1) → (S,R,R)-α-tocopheryl methyl ether (79434-97-2) + C30H52O2 (79434-92-7) + C30H52O2 (79434-94-9) + C30H52O2 (79434-96-1) + C30H52O2 (79434-98-3) + C30H52O2 (79434-93-8) + C30H52O2 (79434-95-0) + (2R,4'R,8'R)-α-tocopheryl methyl ether (32466-45-8)

Guidance literature:

With potassium hydroxide; In 1,2-dimethoxyethane; water; at 50 ℃;

Reference yield: 84.0%

(S,R,R)-α-tocopheryl methyl ether (79434-97-2) → vitamin E (18920-63-3,18920-62-2)

Guidance literature:

With aluminum (III) chloride; boron trifluoride dimethyl sulfide; In dichloromethane; acetonitrile; at 0 - 20 ℃; for 6h;

DOI:10.1002/anie.200801765

upstream raw materials:

vitamin E

dimethyl sulfate

C₃₉H₅₅ClO₅

acetic anhydride

Downstream raw materials:

vitamin E