Technology Process of C25H22ClFN6O
There total 8 articles about C25H22ClFN6O which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine; HATU;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 16h;
DOI:10.1016/j.bmcl.2014.03.079
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium hydroxide / water; tetrahydrofuran / 12 h / 20 °C
2: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C
With
N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.03.079
- Guidance literature:
-
Multi-step reaction with 4 steps
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / 1,4-dioxane; water / 16 h / 110 °C
2: cesium fluoride / dimethyl sulfoxide / 48 h / 120 °C
3: lithium hydroxide / water; tetrahydrofuran / 12 h / 20 °C
4: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; N-ethyl-N,N-diisopropylamine; cesium fluoride; HATU; lithium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.03.079
