2-[2-[2-{2-[2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionic acid methyl ester

Base Information

• Chemical Name: 2-[2-[2-{2-[2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionic acid methyl ester
• CAS No.: 808771-91-7
• Molecular Formula: C₆₄H₆₈N₈O₁₁
• Molecular Weight: 1125.29

Synonyms:

Chemical Property of 2-[2-[2-{2-[2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-[2-{2-[2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionic acid methyl ester

There total 6 articles about 2-[2-[2-{2-[2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Nα-(tert-butoxycarbonyl)-L-tryptophyl-L-phenylalanine methyl ester (72156-62-8) → 2-[2-[2-{2-[2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionic acid methyl ester (808771-91-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / trifluoroacetic acid / CH₂Cl₂; methoxybenzene

2: O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; ethyldiisopropylamine / CH₂Cl₂

3: trifluoroacetic acid / CH₂Cl₂; methoxybenzene

4: O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; ethyldiisopropylamine / acetonitrile

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; methoxybenzene; acetonitrile;

DOI:10.1016/j.bmc.2006.03.028

Reference yield:

2-[2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionic acid methyl ester (808771-72-4) → 2-[2-[2-{2-[2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionic acid methyl ester (808771-91-7)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / CH₂Cl₂; methoxybenzene

2: O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; ethyldiisopropylamine / acetonitrile

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; methoxybenzene; acetonitrile;

DOI:10.1016/j.bmc.2006.03.028

Reference yield:

methyl (2S)-2-amino-3-phenylpropanoate (2577-90-4) → 2-[2-[2-{2-[2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionic acid methyl ester (808771-91-7)

Guidance literature:

Multi-step reaction with 5 steps

1: O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; ethyldiisopropylamine / CH₂Cl₂

2: 100 percent / trifluoroacetic acid / CH₂Cl₂; methoxybenzene

3: O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; ethyldiisopropylamine / CH₂Cl₂

4: trifluoroacetic acid / CH₂Cl₂; methoxybenzene

5: O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; ethyldiisopropylamine / acetonitrile

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; methoxybenzene; acetonitrile;

DOI:10.1016/j.bmc.2006.03.028

upstream raw materials:

N^α-(tert-butoxycarbonyl)-L-tryptophyl-L-phenylalanine methyl ester

2-[2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionic acid methyl ester

methyl (2S)-2-amino-3-phenylpropanoate

Boc-Trp-OH

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