Technology Process of Ac-D-His-Phe-GlyNH2
There total 2 articles about Ac-D-His-Phe-GlyNH2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-tert-butoxycarbonyl-L-phenylalanine; glycinamide hydrochloride;
With
benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide;
at 20 ℃;
for 0.25h;
Inert atmosphere;
Microwave irradiation;
With
trifluoroacetic acid;
In
dichloromethane;
for 0.5h;
Inert atmosphere;
N-e-Acetyl-D-lysine;
With
benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide;
at 20 ℃;
for 0.25h;
Inert atmosphere;
Microwave irradiation;
DOI:10.1021/jm301213s
- Guidance literature:
-
N-tert-butoxycarbonyl-L-phenylalanine; glycinamide hydrochloride;
With
benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide;
at 20 ℃;
for 0.25h;
Inert atmosphere;
Microwave irradiation;
With
trifluoroacetic acid;
In
dichloromethane;
for 0.5h;
Inert atmosphere;
Nα-acetyl-D-histidine;
With
benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide;
at 20 ℃;
for 0.25h;
Inert atmosphere;
Microwave irradiation;
DOI:10.1021/jm301213s
