(S)-2-[5-((S)-1-Acetoxy-2-{(S)-3-carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid benzyl ester

Base Information

Chemical Name:(S)-2-[5-((S)-1-Acetoxy-2-{(S)-3-carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid benzyl ester
CAS No.:197067-87-1
Molecular Formula:C₃₆H₃₆N₈O₇
Molecular Weight:692.731
Hs Code.:

(S)-2-[5-((S)-1-Acetoxy-2-{(S)-3-carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid benzyl ester

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Chemical Property of (S)-2-[5-((S)-1-Acetoxy-2-{(S)-3-carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid benzyl ester

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Technology Process of (S)-2-[5-((S)-1-Acetoxy-2-{(S)-3-carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid benzyl ester

There total 1 articles about (S)-2-[5-((S)-1-Acetoxy-2-{(S)-3-carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136465-98-0
(2S)-2-[(quinoline-2-carbonyl)-amino]-succinamic acid

: (1'S,2''S)-5-(1''-Acetoxy-2''-amino-3''-phenylpropyl)-1-(1'-benzyloxycarbonylethyl)-1H-tetrazole hydrobromide

: 197067-87-1
(S)-2-[5-((S)-1-Acetoxy-2-{(S)-3-carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid benzyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; for 48h; Ambient temperature;
DOI:10.1039/a702458d

Reference yield:

: 197067-87-1
(S)-2-[5-((S)-1-Acetoxy-2-{(S)-3-carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid benzyl ester

: Acetic acid (1R,2S)-1-[1-((R)-1-tert-butylcarbamoyl-ethyl)-1H-tetrazol-5-yl]-2-{(S)-3-carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: AcOH, H₂ / 10percent Pd/C / ethanol / 18 h / Ambient temperature

2: Et₃N, BOP / CH₂Cl₂; dimethylformamide / 1 h / Ambient temperature

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/a702458d

Reference yield:

: 197067-87-1
(S)-2-[5-((S)-1-Acetoxy-2-{(S)-3-carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid benzyl ester

: Acetic acid (1R,2S)-1-[1-((S)-1-tert-butylcarbamoyl-ethyl)-1H-tetrazol-5-yl]-2-{(S)-3-carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: AcOH, H₂ / 10percent Pd/C / ethanol / 18 h / Ambient temperature

2: Et₃N, BOP / CH₂Cl₂; dimethylformamide / 1 h / Ambient temperature

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/a702458d