4-methoxybenzoic acid 5-(4-amino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-2,5-dihydrofuran-2-ylmethyl ester

Base Information

Chemical Name:4-methoxybenzoic acid 5-(4-amino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-2,5-dihydrofuran-2-ylmethyl ester
CAS No.:869383-89-1
Molecular Formula:C₁₇H₁₆FN₃O₅
Molecular Weight:361.33
Hs Code.:

Synonyms:

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Chemical Property of 4-methoxybenzoic acid 5-(4-amino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-2,5-dihydrofuran-2-ylmethyl ester

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 4-methoxybenzoic acid 5-(4-amino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-2,5-dihydrofuran-2-ylmethyl ester

There total 4 articles about 4-methoxybenzoic acid 5-(4-amino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-2,5-dihydrofuran-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 869383-87-9
1,2-O-isopropylidene-3,5-di-O-p-methoxybenzoyl-α-D-xylofuranose

: 869383-89-1
4-methoxybenzoic acid 5-(4-amino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-2,5-dihydrofuran-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂SO₄ / acetic acid; H₂O / 5 h / 95 °C

2: 23 percent / I₂; polymer bound triphenylphosphine; imidazole / CH₂Cl₂ / 1 h / 20 °C

3: 35 percent / DBU / Pd(Ph₃P)4 / acetonitrile; 1-methyl-pyrrolidin-2-one / 48 h / 33 °C

With 1H-imidazole; polymer bound triphenylphosphine; sulfuric acid; iodine; 1,8-diazabicyclo[5.4.0]undec-7-ene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; dichloromethane; water; acetic acid; acetonitrile; 3: Ferrier rearrangement;
DOI:10.1016/j.tetlet.2005.09.139

Reference yield:

: 3,5-di-O-p-methoxybenzoyl-D-xylofuranose

: 869383-89-1
4-methoxybenzoic acid 5-(4-amino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-2,5-dihydrofuran-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 23 percent / I₂; polymer bound triphenylphosphine; imidazole / CH₂Cl₂ / 1 h / 20 °C

2: 35 percent / DBU / Pd(Ph₃P)4 / acetonitrile; 1-methyl-pyrrolidin-2-one / 48 h / 33 °C

With 1H-imidazole; polymer bound triphenylphosphine; iodine; 1,8-diazabicyclo[5.4.0]undec-7-ene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; dichloromethane; acetonitrile; 2: Ferrier rearrangement;
DOI:10.1016/j.tetlet.2005.09.139

Reference yield:

: 100-07-2
4-methoxy-benzoyl chloride

: 869383-89-1
4-methoxybenzoic acid 5-(4-amino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-2,5-dihydrofuran-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95.4 percent / pyridine / 6.5 h / 60 - 65 °C

2: H₂SO₄ / acetic acid; H₂O / 5 h / 95 °C

3: 23 percent / I₂; polymer bound triphenylphosphine; imidazole / CH₂Cl₂ / 1 h / 20 °C

4: 35 percent / DBU / Pd(Ph₃P)4 / acetonitrile; 1-methyl-pyrrolidin-2-one / 48 h / 33 °C

With pyridine; 1H-imidazole; polymer bound triphenylphosphine; sulfuric acid; iodine; 1,8-diazabicyclo[5.4.0]undec-7-ene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; dichloromethane; water; acetic acid; acetonitrile; 4: Ferrier rearrangement;
DOI:10.1016/j.tetlet.2005.09.139