tert-Butoxycarbonylamino-acetic acid (4aR,6S,7R,8S,8aR)-7-(2-tert-butoxycarbonylamino-acetoxy)-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester

Base Information

Chemical Name:tert-Butoxycarbonylamino-acetic acid (4aR,6S,7R,8S,8aR)-7-(2-tert-butoxycarbonylamino-acetoxy)-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester
CAS No.:100484-43-3
Molecular Formula:C₂₈H₄₀N₂O₁₂
Molecular Weight:596.632
Hs Code.:

tert-Butoxycarbonylamino-acetic acid (4aR,6S,7R,8S,8aR)-7-(2-tert-butoxycarbonylamino-acetoxy)-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester

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Chemical Property of tert-Butoxycarbonylamino-acetic acid (4aR,6S,7R,8S,8aR)-7-(2-tert-butoxycarbonylamino-acetoxy)-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester

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Technology Process of tert-Butoxycarbonylamino-acetic acid (4aR,6S,7R,8S,8aR)-7-(2-tert-butoxycarbonylamino-acetoxy)-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester

There total 1 articles about tert-Butoxycarbonylamino-acetic acid (4aR,6S,7R,8S,8aR)-7-(2-tert-butoxycarbonylamino-acetoxy)-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 4530-20-5
BOC-glycine

: 3162-96-7
methyl 4,6-O-benzylidene-α-D-glucopyranoside

: 100484-43-3
tert-Butoxycarbonylamino-acetic acid (4aR,6S,7R,8S,8aR)-7-(2-tert-butoxycarbonylamino-acetoxy)-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; 1) 0 deg C, 2) RT;
DOI:10.1271/bbb1961.54.1401

Reference yield:

: 100484-43-3
tert-Butoxycarbonylamino-acetic acid (4aR,6S,7R,8S,8aR)-7-(2-tert-butoxycarbonylamino-acetoxy)-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester

: 130015-99-5
C₅₁H₆₂N₈O₁₄*2ClH

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / 4N HCl, formic acid / ethyl acetate / Ambient temperature

2: 85 percent / 1-hydroxybenzotriazole, DCC / dimethylformamide / 1) 0 deg C, 2) RT

3: 68 percent / 1-hydroxybenzotriazole, DCC / dimethylformamide / 1) 0 deg C, 2) RT

4: 93 percent / 4N HCl / dioxane / Ambient temperature

With hydrogenchloride; formic acid; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1271/bbb1961.54.1401

Reference yield:

: 100484-43-3
tert-Butoxycarbonylamino-acetic acid (4aR,6S,7R,8S,8aR)-7-(2-tert-butoxycarbonylamino-acetoxy)-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester

: 130033-98-6
C₅₁H₆₂N₈O₁₄*2ClH

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / 4N HCl, formic acid / ethyl acetate / Ambient temperature

2: 71 percent / 1-hydroxybenzotriazole, DCC / dimethylformamide / 1) 0 deg C, 2) RT

3: 91 percent / 4N HCl / dioxane / Ambient temperature

With hydrogenchloride; formic acid; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1271/bbb1961.54.1401