methyl ((S)-1-(2-(3-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)-2-(4-(pyridin-3-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Base Information

Chemical Name:methyl ((S)-1-(2-(3-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)-2-(4-(pyridin-3-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate
CAS No.:1365541-73-6
Molecular Formula:C₄₃H₅₁N₅O₆
Molecular Weight:733.908
Hs Code.:

methyl ((S)-1-(2-(3-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)-2-(4-(pyridin-3-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

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Chemical Property of methyl ((S)-1-(2-(3-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)-2-(4-(pyridin-3-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

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Technology Process of methyl ((S)-1-(2-(3-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)-2-(4-(pyridin-3-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

There total 12 articles about methyl ((S)-1-(2-(3-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)-2-(4-(pyridin-3-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₅H₇₉N₅O₆Si₂

: 1365541-73-6
methyl ((S)-1-(2-(3-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)-2-(4-(pyridin-3-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 6h;
DOI:10.1021/jm201620t

Reference yield:

: 1365541-34-9
(3S,4S)-3-allyl-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)pyrrolidin-2-one

: 1365541-73-6
methyl ((S)-1-(2-(3-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)-2-(4-(pyridin-3-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 6 h / 20 - 80 °C

2.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; ethanol; water / 2 h / 20 °C

3.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 3 h / 0 - 20 °C

4.1: acetic acid / tetrahydrofuran / 0.33 h / 20 °C / Molecular sieve

4.2: 3 h / 35 °C

5.1: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); palladium diacetate; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate / ISOPROPYLAMIDE; water / 1.5 h / 105 °C / Microwave irradiation

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 °C

With trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tetrabutyl ammonium fluoride; dihydrogen peroxide; palladium diacetate; sulfur trioxide pyridine complex; potassium carbonate; acetic acid; triethylamine; sodium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; ethanol; dichloromethane; ISOPROPYLAMIDE; water; dimethyl sulfoxide; 5.1: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm201620t

Reference yield:

: C₂₉H₃₉NO₃Si

: 1365541-73-6
methyl ((S)-1-(2-(3-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)-2-(4-(pyridin-3-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 0 - 25 °C

2.1: tetrahydrofuran / 6 h / 20 - 80 °C

3.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; ethanol; water / 2 h / 20 °C

4.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 3 h / 0 - 20 °C

5.1: acetic acid / tetrahydrofuran / 0.33 h / 20 °C / Molecular sieve

5.2: 3 h / 35 °C

6.1: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); palladium diacetate; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate / ISOPROPYLAMIDE; water / 1.5 h / 105 °C / Microwave irradiation

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 °C

With trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tetrabutyl ammonium fluoride; dihydrogen peroxide; palladium diacetate; sulfur trioxide pyridine complex; potassium carbonate; acetic acid; triethylamine; sodium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; ethanol; dichloromethane; ISOPROPYLAMIDE; water; dimethyl sulfoxide; 6.1: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm201620t