methyl ((S)-1-(2-(3-((3S,4S)-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Base Information

Chemical Name:methyl ((S)-1-(2-(3-((3S,4S)-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate
CAS No.:1365541-70-3
Molecular Formula:C₅₀H₇₅BrN₄O₆Si₂
Molecular Weight:964.244
Hs Code.:

methyl ((S)-1-(2-(3-((3S,4S)-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Synonyms:methyl ((S)-1-(2-(3-((3S,4S)-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

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Chemical Property of methyl ((S)-1-(2-(3-((3S,4S)-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

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Technology Process of methyl ((S)-1-(2-(3-((3S,4S)-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

There total 12 articles about methyl ((S)-1-(2-(3-((3S,4S)-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 872703-59-8
{(1S)-1-[N'-(4-bromobenzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl}carbamic acid methyl ester

: C₃₅H₅₃NO₄Si₂

: 1365541-70-3
methyl ((S)-1-(2-(3-((3S,4S)-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:: {(1S)-1-[N'-(4-bromobenzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl}carbamic acid methyl ester; C₃₅H₅₃NO₄Si₂; With acetic acid; In tetrahydrofuran; at 20 ℃; for 0.333333h; Molecular sieve;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 35 ℃; for 3h;
DOI:10.1021/jm201620t

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 1365541-70-3
methyl ((S)-1-(2-(3-((3S,4S)-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0 - 25 °C

2.1: tetrahydrofuran / 6 h / 20 - 80 °C

3.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; ethanol; water / 2 h / 20 °C

4.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 3 h / 0 - 20 °C

5.1: acetic acid / tetrahydrofuran / 0.33 h / 20 °C / Molecular sieve

5.2: 3 h / 35 °C

With dihydrogen peroxide; sulfur trioxide pyridine complex; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jm201620t

Reference yield:

: 1365541-34-9
(3S,4S)-3-allyl-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)pyrrolidin-2-one

: 1365541-70-3
methyl ((S)-1-(2-(3-((3S,4S)-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)propyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 6 h / 20 - 80 °C

2.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; ethanol; water / 2 h / 20 °C

3.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 3 h / 0 - 20 °C

4.1: acetic acid / tetrahydrofuran / 0.33 h / 20 °C / Molecular sieve

4.2: 3 h / 35 °C

With dihydrogen peroxide; sulfur trioxide pyridine complex; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jm201620t