C₁₅H₁₆O₃

Base Information

• Chemical Name: C₁₅H₁₆O₃
• CAS No.: 1391852-81-5
• Molecular Formula: C₁₅H₁₆O₃
• Molecular Weight: 244.29
• Mol file: 1391852-81-5.mol

Synonyms:

Chemical Property of C₁₅H₁₆O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₆O₃

There total 5 articles about C₁₅H₁₆O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Phenyl-2-propyn-1-ol (4187-87-5) + 1-acetoxy-2-(chloromethyl)-2-propene (52736-91-1) → C15H16O3 (1391852-81-5)

Guidance literature:

1-Phenyl-2-propyn-1-ol; With copper(l) iodide; tetrabutylammomium bromide; potassium carbonate; In N,N-dimethyl-formamide; at 23 - 25 ℃; for 0.25h; Inert atmosphere;

1-acetoxy-2-(chloromethyl)-2-propene; In N,N-dimethyl-formamide; for 24h; Inert atmosphere;

DOI:10.1002/chem.201103771

Reference yield:

5-(chloromethyl)-1-phenylhex-5-en-2-yn-1-ol (1391852-80-4) + potassium acetate (127-08-2) → C15H16O3 (1391852-81-5)

Guidance literature:

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1002/adsc.201701068

Reference yield:

1-phenyl-3-trimethylsilylprop-2-yn-1-ol (89530-34-7) → C15H16O3 (1391852-81-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; methanol / 20 °C

2: copper(l) iodide; tetrabutylammomium bromide; potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: sodium iodide; potassium carbonate / N,N-dimethyl-formamide / 20 °C

With methanol; copper(l) iodide; tetrabutylammomium bromide; potassium carbonate; sodium iodide; In N,N-dimethyl-formamide;

DOI:10.1002/adsc.201701068

upstream raw materials:

1-Phenyl-2-propyn-1-ol

1-acetoxy-2-(chloromethyl)-2-propene

1-phenyl-3-trimethylsilylprop-2-yn-1-ol

5-(chloromethyl)-1-phenylhex-5-en-2-yn-1-ol

Downstream raw materials:

2-methylene-6-oxo-6-phenylhex-4-yn-1-yl acetate