N-[2-amino-5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)pyridin-3-yl]-2,4-difluorobenzene-1-sulfonamide

Base Information

Chemical Name:N-[2-amino-5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)pyridin-3-yl]-2,4-difluorobenzene-1-sulfonamide
CAS No.:1383987-71-0
Molecular Formula:C₂₅H₁₈F₂N₆O₃S
Molecular Weight:520.519
Hs Code.:

Synonyms:

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Chemical Property of N-[2-amino-5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)pyridin-3-yl]-2,4-difluorobenzene-1-sulfonamide

Chemical Property:

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Technology Process of N-[2-amino-5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)pyridin-3-yl]-2,4-difluorobenzene-1-sulfonamide

There total 7 articles about N-[2-amino-5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)pyridin-3-yl]-2,4-difluorobenzene-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383992-41-3
6-iodo-2-((4-methoxybenzyl)amino)-3-phenylquinazolin-4(3H)-one

: 1383987-71-0
N-[2-amino-5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)pyridin-3-yl]-2,4-difluorobenzene-1-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / 48 h / Reflux

2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere; Sealed tube

3: sodium hydrogencarbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.33 h / 120 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium hydrogencarbonate; trifluoroacetic acid; In 1,4-dioxane;
DOI:10.1021/jm400781h

Reference yield:

: 5326-47-6
2-amino-5-iodobenzoic acid

: 1383987-71-0
N-[2-amino-5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)pyridin-3-yl]-2,4-difluorobenzene-1-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / 1,4-dioxane / 6 h / Reflux

2: trichlorophosphate; phosphorus pentachloride / 20 - 110 °C

3: N-ethyl-N,N-diisopropylamine / 4 h / 80 °C

4: trifluoroacetic acid / 48 h / Reflux

5: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere; Sealed tube

6: sodium hydrogencarbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.33 h / 120 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; phosphorus pentachloride; potassium acetate; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; In 1,4-dioxane;
DOI:10.1021/jm400781h

Reference yield:

: 1383992-40-2
2-chloro-6-iodo-3-phenylquinazolin-4(3H)-one

: 1383987-71-0
N-[2-amino-5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)pyridin-3-yl]-2,4-difluorobenzene-1-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / 4 h / 80 °C

2: trifluoroacetic acid / 48 h / Reflux

3: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere; Sealed tube

4: sodium hydrogencarbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.33 h / 120 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane;
DOI:10.1021/jm400781h