L-Alanine, N-(3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropyl)-, (R)-

Base Information

Chemical Name:L-Alanine, N-(3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropyl)-, (R)-
CAS No.:105678-41-9
Molecular Formula:C₁₃H₁₄F₃NO₄
Molecular Weight:305.254
Hs Code.:
Mol file:105678-41-9.mol

Synonyms:

Suppliers and Price of L-Alanine, N-(3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropyl)-, (R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Alanine, N-(3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropyl)-, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Alanine, N-(3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropyl)-, (R)-

There total 3 articles about L-Alanine, N-(3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropyl)-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141996-65-8
(R)-2-Methoxy-2-phenyl-3-trifluoropropanoyl-L-aspartic anhydride

: 105693-31-0
(R)-MTPA-(R)-Ala-OH

: 105678-41-9
(R)-MTPA-(S)-Ala-OH

Guidance literature:: With hydrogenchloride; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; triphenylphosphine; Multistep reaction; 1.) THF, reflux, 8h. (or tricyclohexylphosphine instead of PPh₃);
DOI:10.1016/S0040-4039(00)97733-5

Reference yield:

: 141996-63-6
(R)-2-Methoxy-2-phenyl-3-trifluoropropanoyl-L-aspartic acid

: 105678-41-9
(R)-MTPA-(S)-Ala-OH

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / Ac₂O / or DCC instead of Ac₂O

2: 1.) Ni-bis(1,5-cyclooctadiene), PPh₃; 2.) aq. HCl / 1.) THF, reflux, 8h. (or tricyclohexylphosphine instead of PPh₃)

With hydrogenchloride; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; acetic anhydride; triphenylphosphine;
DOI:10.1016/S0040-4039(00)97733-5

Reference yield:

: 56-41-7,25191-17-7,18875-37-1
L-alanin

: 39637-99-5,20445-33-4
(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

: 105678-41-9
(R)-MTPA-(S)-Ala-OH

Guidance literature:: Product distribution; the optical purity of the parent amino acid was determined by 1H- and 19F-NMR;
DOI:10.1021/ja00265a053