Technology Process of methyl 3-[3-(benzyloxy)-3-methylbutyl]-3-(cyanomethyl)-2-methoxyindoline-1-carboxylate
There total 6 articles about methyl 3-[3-(benzyloxy)-3-methylbutyl]-3-(cyanomethyl)-2-methoxyindoline-1-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: diisopropylamine; copper(I) bromide / 1,4-dioxane / 2.5 h / 100 °C / Inert atmosphere
3.1: potassium carbonate; 2BF4(1-)*C72H62O2P4Pt2(4+) / water; 1,4-dioxane / 100 °C
3.2: 3 h / 20 °C / Inert atmosphere
4.1: pyridine; hydroxylamine hydrochloride / 3 h / 20 °C / Inert atmosphere
5.1: thionyl chloride / benzene / 12 h / 20 °C / Inert atmosphere
6.1: hydrogenchloride / water / 24 h / 20 °C / Solvolysis
With
pyridine; hydrogenchloride; thionyl chloride; 2BF4(1-)*C72H62O2P4Pt2(4+); hydroxylamine hydrochloride; sodium hydride; potassium carbonate; diisopropylamine; copper(I) bromide;
In
1,4-dioxane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo301817w
DOI:10.1021/jo301817w
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: diisopropylamine; copper(I) bromide / 1,4-dioxane / 2.5 h / 100 °C / Inert atmosphere
3.1: potassium carbonate; 2BF4(1-)*C72H62O2P4Pt2(4+) / water; 1,4-dioxane / 100 °C
3.2: 3 h / 20 °C / Inert atmosphere
4.1: pyridine; hydroxylamine hydrochloride / 3 h / 20 °C / Inert atmosphere
5.1: thionyl chloride / benzene / 12 h / 20 °C / Inert atmosphere
6.1: hydrogenchloride / water / 24 h / 20 °C / Solvolysis
With
pyridine; hydrogenchloride; thionyl chloride; 2BF4(1-)*C72H62O2P4Pt2(4+); hydroxylamine hydrochloride; sodium hydride; potassium carbonate; diisopropylamine; copper(I) bromide;
In
1,4-dioxane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo301817w
DOI:10.1021/jo301817w
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: diisopropylamine; copper(I) bromide / 1,4-dioxane / 2.5 h / 100 °C / Inert atmosphere
2.1: potassium carbonate; 2BF4(1-)*C72H62O2P4Pt2(4+) / water; 1,4-dioxane / 100 °C
2.2: 3 h / 20 °C / Inert atmosphere
3.1: pyridine; hydroxylamine hydrochloride / 3 h / 20 °C / Inert atmosphere
4.1: thionyl chloride / benzene / 12 h / 20 °C / Inert atmosphere
5.1: hydrogenchloride / water / 24 h / 20 °C / Solvolysis
With
pyridine; hydrogenchloride; thionyl chloride; 2BF4(1-)*C72H62O2P4Pt2(4+); hydroxylamine hydrochloride; potassium carbonate; diisopropylamine; copper(I) bromide;
In
1,4-dioxane; water; benzene;
DOI:10.1021/jo301817w
DOI:10.1021/jo301817w
