5-bromo-4-methoxypicolinonitrile

Base Information

• Chemical Name: 5-bromo-4-methoxypicolinonitrile
• CAS No.: 1256823-07-0
• Molecular Formula: C₇H₅BrN₂O
• Molecular Weight: 213.033
• Mol file: 1256823-07-0.mol

Synonyms:

Chemical Property of 5-bromo-4-methoxypicolinonitrile

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-4-methoxypicolinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-4-methoxypicolinonitrile

There total 4 articles about 5-bromo-4-methoxypicolinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

5-bromo-4-methoxypicolinamide (1294003-28-3) → 5-bromo-4-methoxypicolinonitrile (1256823-07-0)

Guidance literature:

With pyridine; oxalyl dichloride; In N,N-dimethyl-formamide; at 0 ℃; for 2h; Inert atmosphere;

Reference yield:

2-cyano-4-methoxylpyridine (36057-44-0) → 5-bromo-4-methoxypicolinonitrile (1256823-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide; sulfuric acid / 18 h / 0 - 55 °C

1.2: pH 10 / Cooling with ice

2.1: oxalyl dichloride; pyridine / N,N-dimethyl-formamide / 1 h / 0 °C

With pyridine; N-Bromosuccinimide; oxalyl dichloride; sulfuric acid; In N,N-dimethyl-formamide;

Reference yield:

4-methoxypyridine (620-08-6,1232006-56-2) → 5-bromo-4-methoxypicolinonitrile (1256823-07-0)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid; dihydrogen peroxide / water / 24 h / Reflux; Inert atmosphere

2: N,N-Dimethylcarbamoyl chloride / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

3: N-Bromosuccinimide; sulfuric acid / 18 h / 0 - 55 °C / Inert atmosphere

4: oxalyl dichloride; pyridine / N,N-dimethyl-formamide / 2 h / 0 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; oxalyl dichloride; sulfuric acid; dihydrogen peroxide; acetic acid; N,N-Dimethylcarbamoyl chloride; In dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

2-cyano-4-methoxylpyridine

5-bromo-4-methoxypicolinamide

4-methoxypyridine

4-methoxypyridine N-oxide

Refernces

• 1、 -. "FUSED MORPHOLINOPYRIMIDINES AND METHODS OF USE THEREOF". . . Retrieved 2015/05/19.
• 2、 -. "NOVEL HETEROARYL IMIDAZOLES AND HETEROARYL TRIAZOLES AS GAMMA-SECRETASE MODULATORS". . . Retrieved 2011/05/06.