N-(1-cyano-2-ethylperoxyethyl)-2-phenylacetamide

Base Information

• Chemical Name: N-(1-cyano-2-ethylperoxyethyl)-2-phenylacetamide
• CAS No.: 169514-00-5
• Molecular Formula: C₁₃H₁₄N₂O₃
• Molecular Weight: 246.266
• Mol file: 169514-00-5.mol

Synonyms:

Chemical Property of N-(1-cyano-2-ethylperoxyethyl)-2-phenylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-cyano-2-ethylperoxyethyl)-2-phenylacetamide

There total 5 articles about N-(1-cyano-2-ethylperoxyethyl)-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylacetyl chloride (103-80-0) + ethyl-2-aminocyano acetate (32683-02-6) → N-(1-cyano-2-ethylperoxyethyl)-2-phenylacetamide (169514-00-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1002/jhet.4401

Reference yield:

ethyl cyanoglyoxylate-2-oxime (3849-21-6) → N-(1-cyano-2-ethylperoxyethyl)-2-phenylacetamide (169514-00-5)

Guidance literature:

With aluminium amalgam; water; anschliessend Behandeln mit Phenylacetylchlorid;

Reference yield:

ethyl 2-cyanoacetate (105-56-6) → N-(1-cyano-2-ethylperoxyethyl)-2-phenylacetamide (169514-00-5)

Guidance literature:

Multi-step reaction with 3 steps

1: phosphoric acid; sodium nitrite; hydrogenchloride / water / 0 - 45 °C / Cooling with ice

2: sodium hydrogencarbonate; sodium dithionite / water / 2 h / 35 °C

3: triethylamine / dichloromethane / 3 h / 20 °C

With hydrogenchloride; sodium dithionite; phosphoric acid; sodium hydrogencarbonate; triethylamine; sodium nitrite; In dichloromethane; water;

DOI:10.1002/jhet.4401

upstream raw materials:

ethyl cyanoglyoxylate-2-oxime

phenylacetyl chloride

ethyl-2-aminocyano acetate

ethyl 2-cyanoacetate

Downstream raw materials:

rac-(±)-β-benzimidazol-2-ylalanine

5-amino-2-benzyl-thiazole-4-carboxylic acid ethyl ester