Technology Process of 3-benzyl-3-azabicyclo[3.1.1]heptane
There total 6 articles about 3-benzyl-3-azabicyclo[3.1.1]heptane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
borane-THF;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 3h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tetrahydrofuran / 3 h / 0 - 20 °C
1.2: 0 - 20 °C
2.1: palladium 10% on activated carbon; hydrogen / ethanol / 1.5 h / 20 °C
3.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
4.1: triethylamine / 0 - 20 °C / Inert atmosphere
4.2: 24 h / Reflux
5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -20 °C / Inert atmosphere
6.1: borane-THF / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
With
lithium borohydride; borane-THF; palladium 10% on activated carbon; hydrogen; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; ethanol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: palladium 10% on activated carbon; hydrogen / ethanol / 1.5 h / 20 °C
2.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
3.1: triethylamine / 0 - 20 °C / Inert atmosphere
3.2: 24 h / Reflux
4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -20 °C / Inert atmosphere
5.1: borane-THF / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
With
lithium borohydride; borane-THF; palladium 10% on activated carbon; hydrogen; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; ethanol;