Piperazine, 1-(benzo[b]thien-7-yl)-

Base Information

• Chemical Name: Piperazine, 1-(benzo[b]thien-7-yl)-
• CAS No.: 105685-06-1
• Molecular Formula: C₁₂H₁₄N₂S
• Molecular Weight: 218.323
• Mol file: 105685-06-1.mol

Synonyms:

Chemical Property of Piperazine, 1-(benzo[b]thien-7-yl)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Piperazine, 1-(benzo[b]thien-7-yl)-

There total 17 articles about Piperazine, 1-(benzo[b]thien-7-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.9%

piperazine (110-85-0) + 7-nitrobenzothiophene (17511-54-5) → 1-(benzo[b]thiophen-7-yl)piperazine (105685-06-1)

Guidance literature:

In dimethyl sulfoxide; at 180 ℃; for 24h;

Reference yield: 55.0%

1-(benzo[b]thiophen-7-yl)piperazine hydrochloride (105684-41-1) → 1-(benzo[b]thiophen-7-yl)piperazine (105685-06-1)

Guidance literature:

With sodium hydroxide; In dichloromethane;

Reference yield:

1-(1-benzothiophen-7-yl)-4-benzylpiperazine → 1-(benzo[b]thiophen-7-yl)piperazine (105685-06-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In tetrahydrofuran; at 45 ℃; for 8h;

upstream raw materials:

piperazine

7-bromobenzo(b)thiophene

7-nitro-benzo[b]thiophene-2-carboxylic acid methyl ester

2-chloro-3-nitrobenzaldehyde

Refernces

• 1、 -. "Crystal form of cyclohexane derivative". Paragraph 0045; 0047-0049. . Retrieved 2020/03/02.
• 2、 -. "Preparation method of 7-piperazinyl benzothiophene or salt thereof". . . Retrieved 2020/05/14.