1-[2-(4-CHLOROPHENYL)-2-OXOETHYL]PYRIDINIUM IODIDE

Base Information

• Chemical Name: 1-[2-(4-CHLOROPHENYL)-2-OXOETHYL]PYRIDINIUM IODIDE
• CAS No.: 105688-33-3
• Molecular Formula: C13H11ClNO.I
• Molecular Weight: 359.594
• Mol file: 105688-33-3.mol

Synonyms:

Chemical Property of 1-[2-(4-CHLOROPHENYL)-2-OXOETHYL]PYRIDINIUM IODIDE

Chemical Property:

• Melting Point: 217-218 °C
• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

1-[2-(4-Chlorophenyl)-2-oxoethyl]pyridinium iodide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-(4-CHLOROPHENYL)-2-OXOETHYL]PYRIDINIUM IODIDE

There total 2 articles about 1-[2-(4-CHLOROPHENYL)-2-OXOETHYL]PYRIDINIUM IODIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyridine (110-86-1) + para-chloroacetophenone (99-91-2) → 1-[2-(4-chloro-phenyl)-2-oxo-ethyl]-pyridinium iodide (105688-33-3)

Guidance literature:

With iodine; for 16h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmcl.2018.03.050

Reference yield: 86.9%

para-chloroacetophenone (99-91-2) → 1-[2-(4-chloro-phenyl)-2-oxo-ethyl]-pyridinium iodide (105688-33-3)

Guidance literature:

With pyridine; iodine; at 140 ℃; for 3h;

DOI:10.1016/j.ejmech.2016.02.050

Reference yield: 91.8%

1-(4-hydroxyphenyl)-3-(thiophen-3-yl)prop-2-en-1-one + 1-[2-(4-chloro-phenyl)-2-oxo-ethyl]-pyridinium iodide (105688-33-3) → 4-(6-(4-chlorophenyl)-4-(thiophen-3-yl)pyridin-2-yl)phenol

Guidance literature:

With ammonium acetate; acetic acid; at 80 - 100 ℃;

DOI:10.1016/j.ejmech.2016.02.050

upstream raw materials:

pyridine

para-chloroacetophenone

Downstream raw materials:

1-[(Z)-1-(4-Chloro-benzoyl)-2-(4-dimethylamino-phenyl)-vinyl]-pyridinium; iodide

C₁₅H₁₂ClNOS₂

2-(4-chlorophenyl)-4-(furan-2-yl)-6-(3-methylthiophen-2-yl)pyridine

2-(4-chlorophenyl)-4-(furan-3-yl)-6-(3-methylthiophen-2-yl)pyridine

Refernces

• 1、 Thapa Magar, Til Bahadur,Kadayat, Tara Man,Lee, Hwa-Jong,Park, Seojeong,Bist, Ganesh,Shrestha, Aarajana,Kwon, Youngjoo,Lee, Eung-Seok. "2-Chlorophenyl-substituted benzofuro[3,2-b]pyridines with enhanced topoisomerase inhibitory activity: The role of the chlorine substituent". . p. 3279 - 3283. Retrieved 2017.
• 2、 Conlon, Ivie L.,Van Eker, Daniel,Abdelmalak, Sameh,Murphy, William A.,Bashir, Hassan,Sun, Michael,Chauhan, Jay,Varney, Kristen M.,Godoy-Ruiz, Raquel,Wilder, Paul T.,Fletcher, Steven. "Kr?hnke pyridines: Rapid and facile access to Mcl-1 inhibitors". . p. 1949 - 1953. Retrieved 2018.
• 3、 Anil, Seegehalli M.,Kiran, Kuppalli R.,Rajeev, Narasimhamurthy,Rangappa, Kanchugarakoppal S.,Sadashiva, Maralinganadoddi P.,Swaroop, Toreshettahally R.. "Cyclization of Active Methylene Isocyanides with α-Oxodithioesters Induced by Base: An Expedient Synthesis of 4-Methylthio/Ethoxycarbonyl-5-acylthiazoles". . p. 1444 - 1450. Retrieved 2020/04/27.
• 4、 Anil, Seegehally M,Kiran, Kuppalli R,Rangappa, Kanchugarakoppal S,Sadashiva, Maralinganadoddi P,Shruthi, Jeegundipattana B,Sukrutha, Kodipura P,Swaroop, Toreshettahally R. "Acid-Catalyzed Condensation of o-Phenylenediammines and o-Aminophenols with α-Oxodithioesters: A Divergent and Regio? selective Synthesis of 2-Methylthio-3-Aryl/Heteroarylquinoxalines and 2-Acylbenzoxazoles". . p. 4205 - 4214. Retrieved 2019/11/14.