1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester

Base Information

Chemical Name:1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester
CAS No.:457884-58-1
Molecular Formula:C₄₃H₅₄Cl₄N₂O₁₀
Molecular Weight:900.721
Hs Code.:

1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester

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Chemical Property of 1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester

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Technology Process of 1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester

There total 5 articles about 1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6914-79-0
1-cyano-cyclopropanecarboxylic acid

: 457884-58-1
1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / H₂, HOAc / Pt₂O

2: 93 percent / NaOH / dioxane

3: 70 percent / DCC / CH₂Cl₂

4: 95 percent / Pd(PPh₃)4, morpholine / tetrahydrofuran

5: DCC, DMAP / CH₂Cl₂

With morpholine; dmap; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; acetic acid; dicyclohexyl-carbodiimide; Adam’s catalyst; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/S0960-894X(98)00748-3

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 457884-58-1
1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / NaOH / dioxane

2: 70 percent / DCC / CH₂Cl₂

3: 95 percent / Pd(PPh₃)4, morpholine / tetrahydrofuran

4: DCC, DMAP / CH₂Cl₂

With morpholine; dmap; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/S0960-894X(98)00748-3

Reference yield:

: 139126-45-7
1-(aminomethyl)cyclopropanecarboxylic acid

: 457884-58-1
1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / NaOH / dioxane

2: 70 percent / DCC / CH₂Cl₂

3: 95 percent / Pd(PPh₃)4, morpholine / tetrahydrofuran

4: DCC, DMAP / CH₂Cl₂

With morpholine; dmap; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/S0960-894X(98)00748-3