Butanamide, 4-[(6-chloro-1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazolin-7-yl)oxy]- N-cyclohexyl-N-methyl-

Base Information

• Chemical Name: Butanamide, 4-[(6-chloro-1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazolin-7-yl)oxy]- N-cyclohexyl-N-methyl-
• CAS No.: 105695-49-6
• Molecular Formula: C₂₁H₂₇ClN₄O₃
• Molecular Weight: 418.923
• Mol file: 105695-49-6.mol

Synonyms:

Chemical Property of Butanamide, 4-[(6-chloro-1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazolin-7-yl)oxy]- N-cyclohexyl-N-methyl-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Butanamide, 4-[(6-chloro-1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazolin-7-yl)oxy]- N-cyclohexyl-N-methyl-

There total 10 articles about Butanamide, 4-[(6-chloro-1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazolin-7-yl)oxy]- N-cyclohexyl-N-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-methylcyclohexylamine (100-60-7) → N-cyclohexyl-N-methyl-4-<(6-chloro-1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide (105695-49-6)

Guidance literature:

Multi-step reaction with 5 steps

1: aq. NaCO₃ / tetrahydrofuran / 1 h / Ambient temperature

2: 1.) AcONa / ethanol / 0.5 h

3: NaBH₃CN / ethanol / 3 h

4: NiCl₂*6H₂O, NaBH₄ / methanol

5: 2.) conc. aq. NH₃ / 1.) EtOH, RT, overnight, 2.) EtOH

With ammonium hydroxide; sodium tetrahydroborate; sodium acetate; sodium cyanoborohydride; nickel dichloride; In tetrahydrofuran; methanol; ethanol;

DOI:10.1021/jm00385a012

Reference yield:

2-chloro-6-nitro-3-hydroxybenzaldehyde (19183-03-0) → N-cyclohexyl-N-methyl-4-<(6-chloro-1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide (105695-49-6)

Guidance literature:

Multi-step reaction with 8 steps

1: 38 g / K₂CO₃ / dimethylformamide

2: 82 percent / 2N HCl / dioxane / 2 h / Heating

3: oxalyl chloride / benzene; dimethylformamide / 0.5 h

4: aq. NaCO₃ / tetrahydrofuran / 1 h / Ambient temperature

5: 1.) AcONa / ethanol / 0.5 h

6: NaBH₃CN / ethanol / 3 h

7: NiCl₂*6H₂O, NaBH₄ / methanol

8: 2.) conc. aq. NH₃ / 1.) EtOH, RT, overnight, 2.) EtOH

With hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; oxalyl dichloride; sodium acetate; sodium cyanoborohydride; potassium carbonate; nickel dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; benzene;

DOI:10.1021/jm00385a012

Reference yield:

4-(2-Chloro-3-formyl-4-nitro-phenoxy)-butyryl chloride → N-cyclohexyl-N-methyl-4-<(6-chloro-1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide (105695-49-6)

Guidance literature:

Multi-step reaction with 5 steps

1: aq. NaCO₃ / tetrahydrofuran / 1 h / Ambient temperature

2: 1.) AcONa / ethanol / 0.5 h

3: NaBH₃CN / ethanol / 3 h

4: NiCl₂*6H₂O, NaBH₄ / methanol

5: 2.) conc. aq. NH₃ / 1.) EtOH, RT, overnight, 2.) EtOH

With ammonium hydroxide; sodium tetrahydroborate; sodium acetate; sodium cyanoborohydride; nickel dichloride; In tetrahydrofuran; methanol; ethanol;

DOI:10.1021/jm00385a012

upstream raw materials:

bromocyane

N-methylcyclohexylamine

2-chloro-6-nitro-3-hydroxybenzaldehyde

ethyl 4-(2-chloro-3-formyl-4-nitrophenoxy)butyric acid

Refernces

• 1、 -. "N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides". . . Retrieved 2008/06/13.