Technology Process of Butanamide,
4-[(6-chloro-1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazolin-7-yl)oxy]-
N-cyclohexyl-N-methyl-
There total 10 articles about Butanamide,
4-[(6-chloro-1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazolin-7-yl)oxy]-
N-cyclohexyl-N-methyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: aq. NaCO3 / tetrahydrofuran / 1 h / Ambient temperature
2: 1.) AcONa / ethanol / 0.5 h
3: NaBH3CN / ethanol / 3 h
4: NiCl2*6H2O, NaBH4 / methanol
5: 2.) conc. aq. NH3 / 1.) EtOH, RT, overnight, 2.) EtOH
With
ammonium hydroxide; sodium tetrahydroborate; sodium acetate; sodium cyanoborohydride; nickel dichloride;
In
tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00385a012
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 38 g / K2CO3 / dimethylformamide
2: 82 percent / 2N HCl / dioxane / 2 h / Heating
3: oxalyl chloride / benzene; dimethylformamide / 0.5 h
4: aq. NaCO3 / tetrahydrofuran / 1 h / Ambient temperature
5: 1.) AcONa / ethanol / 0.5 h
6: NaBH3CN / ethanol / 3 h
7: NiCl2*6H2O, NaBH4 / methanol
8: 2.) conc. aq. NH3 / 1.) EtOH, RT, overnight, 2.) EtOH
With
hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; oxalyl dichloride; sodium acetate; sodium cyanoborohydride; potassium carbonate; nickel dichloride;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00385a012
- Guidance literature:
-
Multi-step reaction with 5 steps
1: aq. NaCO3 / tetrahydrofuran / 1 h / Ambient temperature
2: 1.) AcONa / ethanol / 0.5 h
3: NaBH3CN / ethanol / 3 h
4: NiCl2*6H2O, NaBH4 / methanol
5: 2.) conc. aq. NH3 / 1.) EtOH, RT, overnight, 2.) EtOH
With
ammonium hydroxide; sodium tetrahydroborate; sodium acetate; sodium cyanoborohydride; nickel dichloride;
In
tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00385a012