Imidazo[2,1-b]thiazole-5-carboxylic acid, 2,3-dihydro-6-(4-methylphenyl)-, cyanomethyl ester, 1,1-dioxide

Base Information

• Chemical Name: Imidazo[2,1-b]thiazole-5-carboxylic acid, 2,3-dihydro-6-(4-methylphenyl)-, cyanomethyl ester, 1,1-dioxide
• CAS No.: 105699-28-3
• Molecular Formula: C15H13N3O4S
• Molecular Weight: 331.352
• Mol file: 105699-28-3.mol

Synonyms:

Chemical Property of Imidazo[2,1-b]thiazole-5-carboxylic acid, 2,3-dihydro-6-(4-methylphenyl)-, cyanomethyl ester, 1,1-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazo[2,1-b]thiazole-5-carboxylic acid, 2,3-dihydro-6-(4-methylphenyl)-, cyanomethyl ester, 1,1-dioxide

There total 2 articles about Imidazo[2,1-b]thiazole-5-carboxylic acid, 2,3-dihydro-6-(4-methylphenyl)-, cyanomethyl ester, 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

chloroacetonitrile (107-14-2) + 1,1-Dioxo-6-p-tolyl-2,3-dihydro-1H-1λ6-imidazo[2,1-b]thiazole-5-carboxylic acid (105655-50-3) → 1,1-Dioxo-6-p-tolyl-2,3-dihydro-1H-1λ6-imidazo[2,1-b]thiazole-5-carboxylic acid cyanomethyl ester (105699-28-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 8h; Heating;

Reference yield:

1,1-Dioxo-6-p-tolyl-2,3-dihydro-1H-1λ6-imidazo[2,1-b]thiazole-5-carbaldehyde (105655-55-8) → 1,1-Dioxo-6-p-tolyl-2,3-dihydro-1H-1λ6-imidazo[2,1-b]thiazole-5-carboxylic acid cyanomethyl ester (105699-28-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / KMnO₄ / H₂O; acetone / 14 h / Ambient temperature

2: 85 percent / Et₃N / tetrahydrofuran / 8 h / Heating

With potassium permanganate; triethylamine; In tetrahydrofuran; water; acetone;

Reference yield: 90.0%

1,1-Dioxo-6-p-tolyl-2,3-dihydro-1H-1λ6-imidazo[2,1-b]thiazole-5-carboxylic acid cyanomethyl ester (105699-28-3) → 1,1-Dioxo-6-p-tolyl-2,3-dihydro-1H-1λ6-imidazo[2,1-b]thiazole-5-carboxylic acid carbamoylmethyl ester (105655-56-9)

Guidance literature:

With sulfuric acid; for 8h; Ambient temperature;

upstream raw materials:

chloroacetonitrile

1,1-Dioxo-6-p-tolyl-2,3-dihydro-1H-1λ⁶-imidazo[2,1-b]thiazole-5-carboxylic acid

1,1-Dioxo-6-p-tolyl-2,3-dihydro-1H-1λ⁶-imidazo[2,1-b]thiazole-5-carbaldehyde

Downstream raw materials:

1,1-Dioxo-6-p-tolyl-2,3-dihydro-1H-1λ⁶-imidazo[2,1-b]thiazole-5-carboxylic acid carbamoylmethyl ester

Refernces