2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-5-cyano-7-(trimethylsiloxy)-1,2,5,8,9,10-hexahydroisoquinoline

Base Information

• Chemical Name: 2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-5-cyano-7-(trimethylsiloxy)-1,2,5,8,9,10-hexahydroisoquinoline
• CAS No.: 129265-21-0
• Molecular Formula: C₃₄H₄₁N₃O₅SSi
• Molecular Weight: 631.868
• Mol file: 129265-21-0.mol

Synonyms:

Chemical Property of 2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-5-cyano-7-(trimethylsiloxy)-1,2,5,8,9,10-hexahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-5-cyano-7-(trimethylsiloxy)-1,2,5,8,9,10-hexahydroisoquinoline

There total 36 articles about 2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-5-cyano-7-(trimethylsiloxy)-1,2,5,8,9,10-hexahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

trimethylsilyl cyanide (7677-24-9) + 2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-7-keto-1,2,7,8,9,10-hexahydroisoquinoline (129265-18-5) → (4aR,8aR)-2-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-5-cyano-7-trimethylsilanyloxy-1,2,4a,5,8,8a-hexahydro-isoquinoline-4-carboxylic acid tert-butyl ester (129265-21-0,129265-22-1)

Guidance literature:

With triethylaluminum; In hexane; benzene; at 25 ℃; for 7h;

Reference yield:

trimethylsilyl cyanide (7677-24-9) + 2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-7-keto-1,2,7,8,9,10-hexahydroisoquinoline (129265-18-5) → (4aR,5S,8aR)-2-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-5-cyano-7-trimethylsilanyloxy-1,2,4a,5,8,8a-hexahydro-isoquinoline-4-carboxylic acid tert-butyl ester (129265-21-0,129265-22-1) + 2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-5-cyano-7-(trimethylsiloxy)-1,2,5,8,9,10-hexahydroisoquinoline (129265-21-0,129265-22-1)

Guidance literature:

With triethylaluminum; In hexane; benzene; at 25 ℃; for 7h; Yield given. Title compound not separated from byproducts;

Reference yield:

trimethylsilyl cyanide (7677-24-9) + 2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-7-keto-1,2,7,8,9,10-hexahydroisoquinoline (129265-18-5) → (4aR,5S,8aR)-2-[2-(1-Benzenesulfonyl-1H-indol-3-yl)-ethyl]-5-cyano-7-trimethylsilanyloxy-1,2,4a,5,8,8a-hexahydro-isoquinoline-4-carboxylic acid tert-butyl ester (129265-21-0,129265-22-1) + 2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-5-cyano-7-(trimethylsiloxy)-1,2,5,8,9,10-hexahydroisoquinoline (129265-21-0,129265-22-1)

Guidance literature:

With triethylaluminum; In hexane; benzene; at 25 ℃; for 7h; Yield given. Title compound not separated from byproducts;

upstream raw materials:

trimethylsilyl cyanide

2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-7-keto-1,2,7,8,9,10-hexahydroisoquinoline

2-(3-indole)-ethanol

3-(2-bromoethyl)-1H-indole

Downstream raw materials:

2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-5-cyano-6-methoxy-7-(trimethylsiloxy)-1,2,5,6,7,8,9,10-octahydroisoquinoline

2-<(1-phenylsulfonyl)tryptophyl>-4-(tert-butoxycarbonyl)-5-cyano-6-hydroxy-7-(trimethylsiloxy)-1,2,5,6,7,8,9,10-octahydroisoquinoline