2-Benzyloxy-3-methoxy-8H-dibenzo-8-quinolizinone

Base Information

• Chemical Name: 2-Benzyloxy-3-methoxy-8H-dibenzo-8-quinolizinone
• CAS No.: 176326-69-5
• Molecular Formula: C₂₅H₁₉NO₃
• Molecular Weight: 381.431
• Mol file: 176326-69-5.mol

Synonyms:

Chemical Property of 2-Benzyloxy-3-methoxy-8H-dibenzo-8-quinolizinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Benzyloxy-3-methoxy-8H-dibenzo-8-quinolizinone

There total 1 articles about 2-Benzyloxy-3-methoxy-8H-dibenzo-8-quinolizinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

methyl 2-bromomethylbenzoate (2417-73-4) + 2-benzoyl-7-benzyloxy-1,2-dihydro-6-methoxyisoquinoline-1-carbonitrile (107588-82-9) → 2-Benzyloxy-3-methoxy-8H-dibenzo-8-quinolizinone (176326-69-5)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 4h;

DOI:10.1007/BF00807398

Reference yield:

2-Benzyloxy-3-methoxy-8H-dibenzo-8-quinolizinone (176326-69-5) → (S)-2-Benzyloxy-3-methoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline (98988-24-0)

Guidance literature:

With sodium tetrahydroborate; lithium aluminium tetrahydride; Yield given. Multistep reaction; 1.) THF, room temp., 1 h; reflux, 4 h, 2.) EtOH, reflux, 2 h;

DOI:10.1007/BF00807398

upstream raw materials:

methyl 2-bromomethylbenzoate

2-benzoyl-7-benzyloxy-1,2-dihydro-6-methoxyisoquinoline-1-carbonitrile

Downstream raw materials:

(S)-2-Benzyloxy-3-methoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline

Refernces