98988-24-0

Upstream product

• 133056-46-9 7-Benzyloxy-2-(2-bromo-benzyl)-6-methoxy-1-methylene-1,2,3,4-tetrahydro-isoquinoline 
• 107588-82-9 2-benzoyl-7-benzyloxy-1,2-dihydro-6-methoxyisoquinoline-1-carbonitrile 
• 142066-41-9 2-(chloromethyl)-phenyl methanol 
• 7154-66-7 2-bromobenzoic acid chloride 
• 6630-33-7 ortho-bromobenzaldehyde 
• 110128-36-4 2-Benzyloxy-3-methoxy-5,6,13,13a-tetrahydro-isoquino[3,2-a]isoquinolin-8-one 
• 133056-45-8 N-<2-(4-benzyloxy-3-methoxyphenyl)ethyl>-N-(2-bromobenzyl)acetamide 
• 133056-47-0 (7-Benzyloxy-6-methoxy-1-methylene-3,4-dihydro-1H-isoquinolin-2-yl)-(2-bromo-phenyl)-methanone 
• 133056-44-7 N-(2-bromobenzyl)-2-(4-benzyloxy-3-methoxyphenyl)ethylamine 
• 22231-61-4 2-[4-(benzyloxy)-3-methoxyphenyl]ethylamine 
• 110128-35-3 2-benzyloxy-3-methoxy-5,6-dihydro-8H-dibenzoquinolizin-8-one 
• 67519-22-6 α-hydroxy-α'-cyano-o-xylene 
• 63321-79-9 o-(N,N-dimethylaminomethyl)benzyl alcohol 
• 4385-35-7 isochroman-3-one 

Downstream Products

• 47206-72-4 2,3-dimethoxyberbine 

Relevant academic research and scientific papers

2-(o-tolyl)-4,4-dimethyl-2-oxazolines - A new vehicle for facile convergent synthesis of protoberberine alkaloids

A single step synthesis of 8-oxotetrahydroprotoberberines (57-82%) by the addition of lithiated 2-(o-tolyl)-4,4-dimethyl-2-oxazolines on 3,4- dihydroisoquinolines is described.

Protoberberines from Reissert-Compounds, V [1]: Synthesis of (±)-Bharatamine

Alkylation of the Reissert compound 1 by methyl 2-bromomethylbenzoate (2) followed by spontaneous intramolecular cyclization affords dibenzo[a, g]quinolizinone 4 which in turn can be reduced to benzyl ether 5 by LiAlH4/NaBH4. Debenzy

A RADICAL APPROACH TO BHARATAMINE, A UNIQUE PROTOBERBERINE ALKALOID FROM ALANGIUM LAMARCKII

Bharatamine, a unique racemic protoberberine alkaloid from Alangium Lamarckii, has been synthesized via aryl radical-initiated 1,6-cyclization as the key step.

Reduction of Lactams and Thiolactams by Sodium Borohydride: Application in the Synthesis of Some Alkaloids

Lactams 1a-8a and thiolactams 1b-8b,9a,10b-12b and 13 could be reduced to their corresponding amines in 70-98percent yield by using borohydide-tert-butyl alcohol-methanol mixtures under reflux.Even the vinylogous amide 19 underwent reduction to afford dep

Bharatamine A Novel Protoberberine Alkaloid of Aberrant Biogenetic Origin from Alangium lamarckii Thw.

The structure elucidation and the synthesis of bharatamine, a biogenetic marvel being a protoberberine alkaloid unoxygenated in ring D, and its regioisomer isobharatamine have been discussed in detail.

A Convenient Total Synthesis of (+/-)-Bharatamine and (+/-)-Isobharatamine

N,N-Dimethylbenzylamine (1) on lithiation with n-butyllithium followed by reaction with paraformaldehyde gives the 2-hydroxymethyl derivative (2). 2 on successive reactions with ClCOOEt, KCN and alc.KOH followed by cyclisation furnishes isochroman-3-one (3).Condensation of 3 with phenylethylamines (4a) and (4b), followed by cyclisation (PCl5), reduction (NaBH4), and debenzylation (EtOH-HCl) gives (+/-)-bharatamine (6c) and (+/-)-3-hydroxy-4-methoxy-5,6,13,13a-tetrahydro-8H-dibenzoquinolizine (isobharatamine, 6d), respectively in high yields.