N-[(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-(3,5-dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-5-oxo-pentyl]-2,2,2-trifluoro-acetamide

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Chemical Name:N-[(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-(3,5-dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-5-oxo-pentyl]-2,2,2-trifluoro-acetamide
CAS No.:148064-67-9
Molecular Formula:C₃₀H₄₁F₃N₄O₄Si
Molecular Weight:606.761
Hs Code.:

Synonyms:

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Chemical Property of N-[(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-(3,5-dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-5-oxo-pentyl]-2,2,2-trifluoro-acetamide

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Technology Process of N-[(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-(3,5-dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-5-oxo-pentyl]-2,2,2-trifluoro-acetamide

There total 11 articles about N-[(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-(3,5-dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-5-oxo-pentyl]-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1466-67-7
1,3-dibenzylurea

: 148064-67-9
N-[(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-(3,5-dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-5-oxo-pentyl]-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 11 steps

1: 2) ethyl acetate, reflux

2: LiBH₄ / diethyl ether

3: Zn(N₃)2(py)2, Ph₃P, DEAD, imid / toluene

4: H₂ / 10percent Pd/C / ethanol

5: pyridine / CH₂Cl₂

6: TBAF / tetrahydrofuran / 0 to 25 deg C

7: (COCl)2, DMSO, DIPEA / CH₂Cl₂

8: BF₃*Et₂O / CH₂Cl₂ / -78 - -20 °C

9: DIPEA / CH₂Cl₂ / 0 °C

10: OsO₄, NMO / acetone; butan-1-ol; H₂O

11: NaIO₄ / tetrahydrofuran; H₂O

With pyridine; 1H-imidazole; sodium periodate; osmium(VIII) oxide; lithium borohydride; N-methyl-2-indolinone; oxalyl dichloride; Zn(N₃)2/bis-pyridine complex; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; acetone; toluene; butan-1-ol;
DOI:10.1021/jo00062a003

Reference yield:

: 148064-50-0
1,3-Dibenzyl-5-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-1-hydroxymethyl-ethyl]-[1,3,5]triazinan-2-one

: 148064-67-9
N-[(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-(3,5-dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-5-oxo-pentyl]-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 9 steps

1: Zn(N₃)2(py)2, Ph₃P, DEAD, imid / toluene

2: H₂ / 10percent Pd/C / ethanol

3: pyridine / CH₂Cl₂

4: TBAF / tetrahydrofuran / 0 to 25 deg C

5: (COCl)2, DMSO, DIPEA / CH₂Cl₂

6: BF₃*Et₂O / CH₂Cl₂ / -78 - -20 °C

7: DIPEA / CH₂Cl₂ / 0 °C

8: OsO₄, NMO / acetone; butan-1-ol; H₂O

9: NaIO₄ / tetrahydrofuran; H₂O

With pyridine; 1H-imidazole; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; oxalyl dichloride; Zn(N₃)2/bis-pyridine complex; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; acetone; toluene; butan-1-ol;
DOI:10.1021/jo00062a003

Reference yield:

: 148064-51-1
5-[(S)-1-Azidomethyl-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1,3-dibenzyl-[1,3,5]triazinan-2-one

: 148064-67-9
N-[(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-(3,5-dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-5-oxo-pentyl]-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: H₂ / 10percent Pd/C / ethanol

2: pyridine / CH₂Cl₂

3: TBAF / tetrahydrofuran / 0 to 25 deg C

4: (COCl)2, DMSO, DIPEA / CH₂Cl₂

5: BF₃*Et₂O / CH₂Cl₂ / -78 - -20 °C

6: DIPEA / CH₂Cl₂ / 0 °C

7: OsO₄, NMO / acetone; butan-1-ol; H₂O

8: NaIO₄ / tetrahydrofuran; H₂O

With pyridine; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; oxalyl dichloride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; acetone; butan-1-ol;
DOI:10.1021/jo00062a003