Technology Process of (S)-2-(Trityl-amino)-propionic acid (S)-1-((2S,3S)-3-decyl-4-oxo-oxetan-2-ylmethyl)-octyl ester
There total 12 articles about (S)-2-(Trityl-amino)-propionic acid (S)-1-((2S,3S)-3-decyl-4-oxo-oxetan-2-ylmethyl)-octyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
1.) 0 deg C, 2 h, 2.) r.t., overnight;
DOI:10.1039/a800807h
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 82 percent / H2, HCl / Ru<(R)BINAP>2 / methanol / 48 h / 40 °C / 10343 Torr
2: 75 percent / imidazole / dimethylformamide / 16 h / Ambient temperature
3: 66 percent / DIBAL-H / CH2Cl2; toluene / 0.5 h / -80 °C
4: 57 percent / EtAlCl2 / diethyl ether; hexane / 1.) -50 deg C, 10 min, 2.) -50 deg C to -4 deg C
5: 37 percent / HF, H2O / acetonitrile / 4 h / Ambient temperature
6: 93 percent / TBAF*3H2O / tetrahydrofuran / 0.25 h / -90 °C
7: 63 percent / PPh3, DIAD / tetrahydrofuran / 1.) 0 deg C, 2 h, 2.) r.t., overnight
With
1H-imidazole; hydrogenchloride; di-isopropyl azodicarboxylate; hydrogen fluoride; tetrabutyl ammonium fluoride; water; hydrogen; ethylaluminum dichloride; diisobutylaluminium hydride; triphenylphosphine;
Ru<(R)BINAP>2;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1039/a800807h
- Guidance literature:
-
Multi-step reaction with 9 steps
1: pyridine / CH2Cl2 / 1.5 h / Ambient temperature
2: 16 h / Heating
3: 82 percent / H2, HCl / Ru<(R)BINAP>2 / methanol / 48 h / 40 °C / 10343 Torr
4: 75 percent / imidazole / dimethylformamide / 16 h / Ambient temperature
5: 66 percent / DIBAL-H / CH2Cl2; toluene / 0.5 h / -80 °C
6: 57 percent / EtAlCl2 / diethyl ether; hexane / 1.) -50 deg C, 10 min, 2.) -50 deg C to -4 deg C
7: 37 percent / HF, H2O / acetonitrile / 4 h / Ambient temperature
8: 93 percent / TBAF*3H2O / tetrahydrofuran / 0.25 h / -90 °C
9: 63 percent / PPh3, DIAD / tetrahydrofuran / 1.) 0 deg C, 2 h, 2.) r.t., overnight
With
pyridine; 1H-imidazole; hydrogenchloride; di-isopropyl azodicarboxylate; hydrogen fluoride; tetrabutyl ammonium fluoride; water; hydrogen; ethylaluminum dichloride; diisobutylaluminium hydride; triphenylphosphine;
Ru<(R)BINAP>2;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1039/a800807h
