methyl 6-(dibenzylamino)-5-methylnicotinate

Base Information

• Chemical Name: methyl 6-(dibenzylamino)-5-methylnicotinate
• CAS No.: 1318759-81-7
• Molecular Formula: C₂₂H₂₂N₂O₂
• Molecular Weight: 346.429
• Mol file: 1318759-81-7.mol

Synonyms:

Chemical Property of methyl 6-(dibenzylamino)-5-methylnicotinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 6-(dibenzylamino)-5-methylnicotinate

There total 3 articles about methyl 6-(dibenzylamino)-5-methylnicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl pyrazole-4-carboxylate (51105-90-9,54866-59-0) → methyl 6-(dibenzylamino)-5-methylnicotinate (1318759-81-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 20 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: sodium periodate / dichloromethane / 2 h / 22 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: chloroform / 0.25 h / 22 °C

With sodium periodate; sodium hydride; In dichloromethane; chloroform; N,N-dimethyl-formamide; mineral oil; 3.1: Diels-Alder reaction;

DOI:10.1021/ja204856a

Reference yield:

methyl 1-amino-1H-pyrazole-4-carboxylate (150017-46-2) → methyl 6-(dibenzylamino)-5-methylnicotinate (1318759-81-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium periodate / dichloromethane / 2 h / 22 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: chloroform / 0.25 h / 22 °C

With sodium periodate; In dichloromethane; chloroform; 2.1: Diels-Alder reaction;

DOI:10.1021/ja204856a

Reference yield:

methyl 1-trityl-1H-pyrazole-4-carboxylate (875554-08-8) → methyl 6-(dibenzylamino)-5-methylnicotinate (1318759-81-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride / methanol; dichloromethane; water / 3 h / 40 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

3.1: sodium periodate / dichloromethane / 2 h / 22 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: chloroform / 0.25 h / 22 °C

With hydrogenchloride; sodium periodate; sodium hydride; In methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; mineral oil; 4.1: Diels-Alder reaction;

DOI:10.1021/ja204856a

upstream raw materials:

methyl pyrazole-4-carboxylate

methyl 1-trityl-1H-pyrazole-4-carboxylate

methyl 1-amino-1H-pyrazole-4-carboxylate