Lipoamido-PEG3-alcohol

Base Information

• Chemical Name: Lipoamido-PEG3-alcohol
• CAS No.: 1342764-64-0
• Molecular Formula: C₁₆H₃₁NO₅S₂
• Molecular Weight: 381.558
• Mol file: 1342764-64-0.mol

Synonyms:

Chemical Property of Lipoamido-PEG3-alcohol

Chemical Property:

• Boiling Point: 573.8±40.0 °C(Predicted)
• PKA: 14.36±0.10(Predicted)
• Density: 1.158±0.06 g/cm3(Predicted)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Lipoamido-PEG3-alcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Lipoamido-PEG3-alcohol has lipoamide and hydroxyl end groups. The hydroxyl group can undergo reactions to further derivatize the compoud. The hydrophilic PEG chain increases the water solubility of the compound in aqueous environments.

Technology Process of Lipoamido-PEG3-alcohol

There total 8 articles about Lipoamido-PEG3-alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

perfluorophenyl 5-(1,2-dithiolan-3-yl)pentanoate (1021338-91-9) + 11-amino-3,6,9-trioxaundecanol (86770-74-3) → C16H31NO5S2 (1342764-64-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 18h;

DOI:10.1021/acs.langmuir.8b03196

Reference yield: 70.0%

11-amino-3,6,9-trioxaundecanol (86770-74-3) + thioctic acid-N-hydroxysuccinimide ester (40846-94-4) → C16H31NO5S2 (1342764-64-0)

Guidance literature:

With sodium hydrogencarbonate; In water; at 4 - 20 ℃; for 25.5h;

DOI:10.1002/anie.201307232

Reference yield: 51.0%

11-amino-3,6,9-trioxaundecanol (86770-74-3) + Thioctic acid (1077-28-7,62-46-4) → C16H31NO5S2 (1342764-64-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c4tb00608a

upstream raw materials:

Thioctic acid

p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester

2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol

11-amino-3,6,9-trioxaundecanol

Downstream raw materials:

N-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)-5-(1,2-dithiolan-3-yl)pentanamide

Refernces

• 1、 Benito-Alifonso, David,Tremel, Shirley,Hou, Bo,Lockyear, Harriet,Mantell, Judith,Fermin, David J.,Verkade, Paul,Berry, Monica,Galan, M. Carmen. "Lactose as a "trojan horse" for quantum dot cell transport". . p. 810 - 814. Retrieved 2014.