4-methyl-2-oxo-2H-chromen-7-yl chloroacetate

Base Information

• Chemical Name: 4-methyl-2-oxo-2H-chromen-7-yl chloroacetate
• CAS No.: 105738-24-7
• Molecular Formula: C12H9ClO4
• Molecular Weight: 252.654
• Hs Code.: 2932209090
• DSSTox Substance ID: DTXSID80352357
• Nikkaji Number: J2.342.741I
• Wikidata: Q82129448
• Mol file: 105738-24-7.mol

Synonyms:105738-24-7;4-methyl-2-oxo-2H-chromen-7-yl chloroacetate;4-methyl-2-oxo-2H-chromen-7-yl 2-chloroacetate;(4-methyl-2-oxochromen-7-yl) 2-chloroacetate;C12H9ClO4;CHLORO-ACETIC ACID 4-METHYL-2-OXO-2H-CHROMEN-7-YL ESTER;7-Chloroacetoxy-4-methylcoumarin;DTXSID80352357;BBL011633;MFCD01034923;STK802474;AKOS000274711;VS-02989;UPCMLD0ENAT0505-6923:001;EU-0066585;FT-0683483;EN300-234920;Z56806276;F0855-0004

Chemical Property of 4-methyl-2-oxo-2H-chromen-7-yl chloroacetate

Chemical Property:

• Vapor Pressure: 9.21E-07mmHg at 25°C
• Boiling Point: 404.8oC at 760 mmHg
• Flash Point: 175.6oC
• PSA: 56.51000
• LogP: 2.24560
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 252.0189365
• Heavy Atom Count: 17
• Complexity: 364

Purity/Quality:

97% ^*data from raw suppliers

4-Methyl-2-oxo-2H-chromen-7-ylChloroacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=O)OC2=C1C=CC(=C2)OC(=O)CCl

Technology Process of 4-methyl-2-oxo-2H-chromen-7-yl chloroacetate

There total 4 articles about 4-methyl-2-oxo-2H-chromen-7-yl chloroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

7-hydroxy-4-methyl-chromen-2-one (90-33-5,79566-13-5) + chloroacetyl chloride (79-04-9) → 7-chloroacetyloxy-4-methylcoumarin (105738-24-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tet.2017.07.018

Reference yield:

7-hydroxy-4-methyl-chromen-2-one (90-33-5,79566-13-5) + 2-oxo-2H-chromen-7-yl chloroethanoate (182115-37-3) → 7-hydroxy-2H-chromen-2-one (93-35-6) + 7-chloroacetyloxy-4-methylcoumarin (105738-24-7) + dihydrofuro[2,3-h]coumarin-9-one (182115-42-0)

Guidance literature:

With aluminium trichloride; at 110 - 120 ℃; for 1h;

Reference yield:

recorcinol (108-46-3) → 7-chloroacetyloxy-4-methylcoumarin (105738-24-7)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄ / 20 °C

2: DMAP / dioxane / Heating

With dmap; sulfuric acid; In 1,4-dioxane;

DOI:10.1016/j.tet.2003.08.051

upstream raw materials:

7-hydroxy-4-methyl-chromen-2-one

chloroacetyl chloride

2-oxo-2H-chromen-7-yl chloroethanoate

recorcinol

Downstream raw materials:

7-hydroxy-4-methyl-chromen-2-one

dihydrofuro[2,3-h]coumarin-9-one

4-methyldihydrofuro[2,3-h]coumarin-9-one

2-chloro-1-(2,4-dimethyl-phenyl)-ethanone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 105738-24-7 CHLORO-ACETIC ACID 4-METHYL-2-OXO-2H-CHROMEN-7-YL ESTER

Send

Send

Metric Ton KG G Pound L ML

Send

Send