2-{2-[4-bromo-1-methyl-2-(methylsulfanyl)-1H-imidazol-5-yl]prop-2-en-1-yl}-6-methylpyrazine

Base Information

Chemical Name:2-{2-[4-bromo-1-methyl-2-(methylsulfanyl)-1H-imidazol-5-yl]prop-2-en-1-yl}-6-methylpyrazine
CAS No.:138336-10-4
Molecular Formula:C₁₃H₁₅BrN₄S
Molecular Weight:339.259
Hs Code.:
Mol file:138336-10-4.mol

Synonyms:Pyrazine,2-[2-[4-bromo-1-methyl-2-(methylthio)-1H-imidazol-5-yl]-2-propenyl]-6-methyl-(9CI)

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Chemical Property of 2-{2-[4-bromo-1-methyl-2-(methylsulfanyl)-1H-imidazol-5-yl]prop-2-en-1-yl}-6-methylpyrazine

Chemical Property:

Vapor Pressure:9.98E-09mmHg at 25°C
Boiling Point:462.3°C at 760 mmHg
Flash Point:233.4°C
Density:1.45g/cm³

Purity/Quality:

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Technology Process of 2-{2-[4-bromo-1-methyl-2-(methylsulfanyl)-1H-imidazol-5-yl]prop-2-en-1-yl}-6-methylpyrazine

There total 5 articles about 2-{2-[4-bromo-1-methyl-2-(methylsulfanyl)-1H-imidazol-5-yl]prop-2-en-1-yl}-6-methylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108905-63-1
Methyl 4-bromo-1-methyl-2-methylthio-5-imidazolecarboxylate

: 138336-10-4
2-[2-(5-Bromo-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl)-allyl]-6-methyl-pyrazine

Guidance literature:: Multi-step reaction with 4 steps

1: 1) LDA, 2) LiOMe / 1) THF, -78 deg C, 1 h, 2) THF, -5 deg C

2: 99 percent / trifluoroacetic acid / 24 h / Heating

3: 1) LDA / 1) THF, hexanes, -78 deg C, 2) THF, -6 to -1 deg C, 15 min

4: methanesulfonic acid / toluene / 0.33 h / Heating

With methanesulfonic acid; lithium methanolate; trifluoroacetic acid; lithium diisopropyl amide; In toluene;
DOI:10.1021/jo00031a017

Reference yield:

: 108-50-9
2,6-dimethylpyrazine

: 138336-10-4
2-[2-(5-Bromo-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl)-allyl]-6-methyl-pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: 1) LDA / 1) THF, hexanes, -78 deg C, 2) THF, -6 to -1 deg C, 15 min

2: methanesulfonic acid / toluene / 0.33 h / Heating

With methanesulfonic acid; lithium diisopropyl amide; In toluene;
DOI:10.1021/jo00031a017

Reference yield:

: 138335-97-4
1-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)ethanone

: 138336-10-4
2-[2-(5-Bromo-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl)-allyl]-6-methyl-pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: 1) LDA / 1) THF, hexanes, -78 deg C, 2) THF, -6 to -1 deg C, 15 min

2: methanesulfonic acid / toluene / 0.33 h / Heating

With methanesulfonic acid; lithium diisopropyl amide; In toluene;
DOI:10.1021/jo00031a017