tert-butyl (S)-3-(2-((3R,5S)-1-(3-(1-(2-[18F]fluoroethyl)-1H-1,2,3-triazol-4-yl)propanoyl)-5-((pyridin-2-ylamino)methyl)pyrrolidin-3-yloxy)acetamido)-2-(2,4,6-trimethylbenzamido)propanoate

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Chemical Name:tert-butyl (S)-3-(2-((3R,5S)-1-(3-(1-(2-[18F]fluoroethyl)-1H-1,2,3-triazol-4-yl)propanoyl)-5-((pyridin-2-ylamino)methyl)pyrrolidin-3-yloxy)acetamido)-2-(2,4,6-trimethylbenzamido)propanoate
CAS No.:1627606-08-9
Molecular Formula:C₃₆H₄₉FN₈O₆
Molecular Weight:707.835
Hs Code.:

tert-butyl (S)-3-(2-((3R,5S)-1-(3-(1-(2-[18F]fluoroethyl)-1H-1,2,3-triazol-4-yl)propanoyl)-5-((pyridin-2-ylamino)methyl)pyrrolidin-3-yloxy)acetamido)-2-(2,4,6-trimethylbenzamido)propanoate

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Chemical Property of tert-butyl (S)-3-(2-((3R,5S)-1-(3-(1-(2-[18F]fluoroethyl)-1H-1,2,3-triazol-4-yl)propanoyl)-5-((pyridin-2-ylamino)methyl)pyrrolidin-3-yloxy)acetamido)-2-(2,4,6-trimethylbenzamido)propanoate

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Technology Process of tert-butyl (S)-3-(2-((3R,5S)-1-(3-(1-(2-[18F]fluoroethyl)-1H-1,2,3-triazol-4-yl)propanoyl)-5-((pyridin-2-ylamino)methyl)pyrrolidin-3-yloxy)acetamido)-2-(2,4,6-trimethylbenzamido)propanoate

There total 11 articles about tert-butyl (S)-3-(2-((3R,5S)-1-(3-(1-(2-[18F]fluoroethyl)-1H-1,2,3-triazol-4-yl)propanoyl)-5-((pyridin-2-ylamino)methyl)pyrrolidin-3-yloxy)acetamido)-2-(2,4,6-trimethylbenzamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 894793-02-3
2-[18F]fluoroethylazide

: 1627606-06-7
tert-butyl (2S)-3-(2-((3R,5S)-1-(pent-4-ynoyl)-5-((pyridin-2-ylamino)methyl)pyrrolidin-3-yloxy)acetamido)-2-(2,4,6-trimethylbenzamido)propanoate

: 1627606-08-9
tert-butyl (S)-3-(2-((3R,5S)-1-(3-(1-(2-[18F]fluoroethyl)-1H-1,2,3-triazol-4-yl)propanoyl)-5-((pyridin-2-ylamino)methyl)pyrrolidin-3-yloxy)acetamido)-2-(2,4,6-trimethylbenzamido)propanoate

Guidance literature:: With copper(II) sulfate; sodium L-ascorbate; In water; acetonitrile; at 20 ℃; for 0.25h;
DOI:10.1002/jlcr.3190

Reference yield:

: C₁₈H₃₁NO₅Si

: 1627606-08-9
tert-butyl (S)-3-(2-((3R,5S)-1-(3-(1-(2-[18F]fluoroethyl)-1H-1,2,3-triazol-4-yl)propanoyl)-5-((pyridin-2-ylamino)methyl)pyrrolidin-3-yloxy)acetamido)-2-(2,4,6-trimethylbenzamido)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C

2: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 °C

3: titanium(IV) isopropylate / 1,2-dichloro-ethane / 20 °C

4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 4 h / 20 °C

5: sodium L-ascorbate; copper(II) sulfate / water; acetonitrile / 0.25 h / 20 °C

With titanium(IV) isopropylate; dmap; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; copper(II) sulfate; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-ethane; acetonitrile; 5: |Huisgen Cycloaddition;
DOI:10.1002/jlcr.3190

Reference yield:

: 1627606-01-2
methyl (2S,4R)-4-hydroxy-1-(pent-4-ynoyl)pyrrolidine-2-carboxylate

: 1627606-08-9
tert-butyl (S)-3-(2-((3R,5S)-1-(3-(1-(2-[18F]fluoroethyl)-1H-1,2,3-triazol-4-yl)propanoyl)-5-((pyridin-2-ylamino)methyl)pyrrolidin-3-yloxy)acetamido)-2-(2,4,6-trimethylbenzamido)propanoate

Guidance literature:: Multi-step reaction with 9 steps

1: sodium hydride; tetra-(n-butyl)ammonium iodide / tetrahydrofuran; paraffin oil / Inert atmosphere

2: lithium chloride; sodium tetrahydroborate / tetrahydrofuran; ethanol / 0 - 20 °C

3: 1H-imidazole / N,N-dimethyl-formamide / 3 h / 20 °C

4: lithium hydroxide monohydrate / methanol / 4 h / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C

6: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 °C

7: titanium(IV) isopropylate / 1,2-dichloro-ethane / 20 °C

8: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 4 h / 20 °C

9: sodium L-ascorbate; copper(II) sulfate / water; acetonitrile / 0.25 h / 20 °C

With 1H-imidazole; titanium(IV) isopropylate; dmap; sodium tetrahydroborate; lithium hydroxide monohydrate; sulfur trioxide pyridine complex; tetra-(n-butyl)ammonium iodide; sodium tris(acetoxy)borohydride; sodium hydride; copper(II) sulfate; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; paraffin oil; 9: |Huisgen Cycloaddition;
DOI:10.1002/jlcr.3190