Technology Process of (4R,4aS,6R,8S,8aR)-6,8-Bis-(tert-butyl-dimethyl-silanyloxy)-4-phenylselanyl-octahydro-isochromen-3-one
There total 15 articles about (4R,4aS,6R,8S,8aR)-6,8-Bis-(tert-butyl-dimethyl-silanyloxy)-4-phenylselanyl-octahydro-isochromen-3-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 12 steps
1: aq. NaOH / tetrahydrofuran / Ambient temperature
2: I2, KI / H2O; CH2Cl2 / Ambient temperature
3: imidazole / dimethylformamide / Ambient temperature
4: 99 percent / DBU / toluene / Heating
5: 89 percent / MCPBA
6: DIBAL / toluene / -78 °C
8: LiAlH4 / tetrahydrofuran / Ambient temperature; or Red-Al
9: p-TsOH / tetrahydrofuran
10: 86 percent / imidazole / dimethylformamide / Ambient temperature
11: 81 percent / NBS / acetone; H2O / -15 °C
12: LDA / tetrahydrofuran / -78 °C
With
1H-imidazole; sodium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; iodine; diisobutylaluminium hydride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; potassium iodide; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/0040-4039(90)80021-D
- Guidance literature:
-
Multi-step reaction with 13 steps
1: p-TsOH / benzene / Ambient temperature
2: aq. NaOH / tetrahydrofuran / Ambient temperature
3: I2, KI / H2O; CH2Cl2 / Ambient temperature
4: imidazole / dimethylformamide / Ambient temperature
5: 99 percent / DBU / toluene / Heating
6: 89 percent / MCPBA
7: DIBAL / toluene / -78 °C
9: LiAlH4 / tetrahydrofuran / Ambient temperature; or Red-Al
10: p-TsOH / tetrahydrofuran
11: 86 percent / imidazole / dimethylformamide / Ambient temperature
12: 81 percent / NBS / acetone; H2O / -15 °C
13: LDA / tetrahydrofuran / -78 °C
With
1H-imidazole; sodium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; iodine; diisobutylaluminium hydride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; potassium iodide; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; benzene;
DOI:10.1016/0040-4039(90)80021-D
