9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ⁵-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-2-[1-methyl-pyrrolidin-(2E)-ylideneamino]-1,9-dihydro-purin-6-one

Base Information

• Chemical Name: 9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ⁵-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-2-[1-methyl-pyrrolidin-(2E)-ylideneamino]-1,9-dihydro-purin-6-one
• CAS No.: 172033-39-5
• Molecular Formula: C₃₈H₄₁N₆O₆PS₃
• Molecular Weight: 804.952

Synonyms:

Chemical Property of 9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ⁵-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-2-[1-methyl-pyrrolidin-(2E)-ylideneamino]-1,9-dihydro-purin-6-one

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Technology Process of 9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ⁵-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-2-[1-methyl-pyrrolidin-(2E)-ylideneamino]-1,9-dihydro-purin-6-one

There total 1 articles about 9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ⁵-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-2-[1-methyl-pyrrolidin-(2E)-ylideneamino]-1,9-dihydro-purin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(N,N-diisopropylamino)-1,3,2-dithiaphospholane (145498-60-8) + 9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-[1-methyl-pyrrolidin-(2E)-ylideneamino]-1,9-dihydro-purin-6-one → 9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ5-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-2-[1-methyl-pyrrolidin-(2E)-ylideneamino]-1,9-dihydro-purin-6-one (172033-39-5)

Guidance literature:

With 1H-tetrazole; sulfur; Yield given. Multistep reaction; 1.) r.t., 1 h, 2.) r.t., overnight;

DOI:10.1021/jo00126a060

Reference yield:

9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ5-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-2-[1-methyl-pyrrolidin-(2E)-ylideneamino]-1,9-dihydro-purin-6-one (172033-39-5) → 2'-Desoxyguanylyl-(3'-5')-2'-desoxyguanosin (15180-30-0)

Guidance literature:

Multi-step reaction with 2 steps

2: butylene 1,2-oxide / aq. ethanol / 3 h / 50 °C

With ethyloxirane; In ethanol;

DOI:10.1021/jo00126a060

upstream raw materials:

2-(N,N-diisopropylamino)-1,3,2-dithiaphospholane

Downstream raw materials:

2'-Desoxyguanylyl-(3'-5')-2'-desoxyguanosin

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