N-(4-Chlorophenyl)-N-(1-methyl-4-piperidinyl)propanamide

Base Information

Chemical Name:N-(4-Chlorophenyl)-N-(1-methyl-4-piperidinyl)propanamide
CAS No.:36796-58-4
Molecular Formula:C₁₅H₂₁ClN₂O
Molecular Weight:280.798
Hs Code.:
DSSTox Substance ID:DTXSID401200952

Synonyms:N-(4-Chlorophenyl)-N-(1-methyl-4-piperidinyl)propanamide;DTXSID401200952;36796-58-4

Suppliers and Price of N-(4-Chlorophenyl)-N-(1-methyl-4-piperidinyl)propanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of N-(4-Chlorophenyl)-N-(1-methyl-4-piperidinyl)propanamide

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:280.1342410
Heavy Atom Count:19
Complexity:295

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC(=O)N(C1CCN(CC1)C)C2=CC=C(C=C2)Cl

Technology Process of N-(4-Chlorophenyl)-N-(1-methyl-4-piperidinyl)propanamide

There total 5 articles about N-(4-Chlorophenyl)-N-(1-methyl-4-piperidinyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445-73-4
1-Methyl-4-piperidone

: 36796-58-4
N-(4-chloro-phenyl)-N-(1-methyl-piperidin-4-yl)-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) p-toluene sulphonic acid; 2.) molecular sieve 4A / toluene / 1.) reflux 7 h; 2.) reflux overnight

2: sodium borohydride / methanol / 2 h / Heating

3: toluene / Heating

With sodium tetrahydroborate; 4 A molecular sieve; toluene-4-sulfonic acid; In methanol; toluene;
DOI:10.1111/j.2042-7158.1988.tb05318.x

Reference yield:

: 36796-47-1
(4-chloro-phenyl)-(1-methyl-piperidin-4-ylidene)-amine

: 36796-58-4
N-(4-chloro-phenyl)-N-(1-methyl-piperidin-4-yl)-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium borohydride / methanol / 2 h / Heating

2: toluene / Heating

With sodium tetrahydroborate; In methanol; toluene;
DOI:10.1111/j.2042-7158.1988.tb05318.x

Reference yield:

: 106-47-8
4-chloro-aniline

: 36796-58-4
N-(4-chloro-phenyl)-N-(1-methyl-piperidin-4-yl)-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) p-toluene sulphonic acid; 2.) molecular sieve 4A / toluene / 1.) reflux 7 h; 2.) reflux overnight

2: sodium borohydride / methanol / 2 h / Heating

3: toluene / Heating

With sodium tetrahydroborate; 4 A molecular sieve; toluene-4-sulfonic acid; In methanol; toluene;
DOI:10.1111/j.2042-7158.1988.tb05318.x