2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-3-(1H-indol-3-yl)-propionic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.1^15,19]octatriaconta-1⁽³⁷⁾,15,17,19⁽³⁸⁾,33,35-hexaen-17-ylmethyl ester

Base Information

• Chemical Name: 2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-3-(1H-indol-3-yl)-propionic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.1^15,19]octatriaconta-1⁽³⁷⁾,15,17,19⁽³⁸⁾,33,35-hexaen-17-ylmethyl ester
• CAS No.: 253170-45-5
• Molecular Formula: C₆₄H₇₁N₃O₁₅
• Molecular Weight: 1122.28

Synonyms:

Chemical Property of 2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-3-(1H-indol-3-yl)-propionic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.1^15,19]octatriaconta-1⁽³⁷⁾,15,17,19⁽³⁸⁾,33,35-hexaen-17-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-3-(1H-indol-3-yl)-propionic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.1^15,19]octatriaconta-1⁽³⁷⁾,15,17,19⁽³⁸⁾,33,35-hexaen-17-ylmethyl ester

There total 16 articles about 2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-3-(1H-indol-3-yl)-propionic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.1^15,19]octatriaconta-1⁽³⁷⁾,15,17,19⁽³⁸⁾,33,35-hexaen-17-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Fmoc L-Phe (35661-40-6) + 2-amino-3-(1H-indol-3-yl)-propionic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.115,19]octatriaconta-1(37),15,17,19(38),33,35-hexaen-17-ylmethyl ester → 2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-3-(1H-indol-3-yl)-propionic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.115,19]octatriaconta-1(37),15,17,19(38),33,35-hexaen-17-ylmethyl ester (253170-45-5)

Guidance literature:

With dmap; diisopropyl-carbodiimide; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/S0040-4039(99)01507-5

Reference yield:

1,11-dichloro-3,6,9-trioxaundecane (638-56-2,27252-69-3) → 2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-3-(1H-indol-3-yl)-propionic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.115,19]octatriaconta-1(37),15,17,19(38),33,35-hexaen-17-ylmethyl ester (253170-45-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 67.1 percent / NaH / dimethylformamide / 2 h / 90 °C

2: 35.1 percent / K₂CO₃ / dimethylformamide / 6 h / 115 °C

3: 90.5 percent / LAH / tetrahydrofuran / 10 h / 20 °C

4: diisipropylcarbodiimide; 4,4-dimethylaminopyridine / CH₂Cl₂ / 0.5 h / 20 °C

5: piperidine / dimethylformamide / 0.13 h / 20 °C

6: diisipropylcarbodiimide; 4,4-dimethylaminopyridine / CH₂Cl₂ / 0.5 h / 20 °C

With piperidine; dmap; lithium aluminium tetrahydride; sodium hydride; potassium carbonate; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: cyclocondensation / 3: Reduction / 4: Esterification / 5: Elimination / 6: Condensation;

DOI:10.1016/S0040-4039(99)01507-5

Reference yield:

1-carbomethoxy-3,5-dihydroxybenzene (2150-44-9) → 2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-3-(1H-indol-3-yl)-propionic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.115,19]octatriaconta-1(37),15,17,19(38),33,35-hexaen-17-ylmethyl ester (253170-45-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 35.1 percent / K₂CO₃ / dimethylformamide / 6 h / 115 °C

2: 90.5 percent / LAH / tetrahydrofuran / 10 h / 20 °C

3: diisipropylcarbodiimide; 4,4-dimethylaminopyridine / CH₂Cl₂ / 0.5 h / 20 °C

4: piperidine / dimethylformamide / 0.13 h / 20 °C

5: diisipropylcarbodiimide; 4,4-dimethylaminopyridine / CH₂Cl₂ / 0.5 h / 20 °C

With piperidine; dmap; lithium aluminium tetrahydride; potassium carbonate; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: cyclocondensation / 2: Reduction / 3: Esterification / 4: Elimination / 5: Condensation;

DOI:10.1016/S0040-4039(99)01507-5

upstream raw materials:

N-Fmoc L-Phe

1,11-dichloro-3,6,9-trioxaundecane

1-carbomethoxy-3,5-dihydroxybenzene

Fmoc-Trp-OH

Downstream raw materials:

4-fluoro-3-nitro-benzoic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.1^15,19]octatriaconta-1⁽³⁷⁾,15,17,19⁽³⁸⁾,33,35-hexaen-17-ylmethyl ester

3-nitro-4-(4-phenyl-piperazin-1-yl)-benzoic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.1^15,19]octatriaconta-1⁽³⁷⁾,15,17,19⁽³⁸⁾,33,35-hexaen-17-ylmethyl ester

2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.1^15,19]octatriaconta-1⁽³⁷⁾,15,17,19⁽³⁸⁾,33,35-hexaen-17-ylmethyl ester

(S)-2-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-3-phenyl-propionic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.1^15,19]octatriaconta-1⁽³⁷⁾,15,17,19⁽³⁸⁾,33,35-hexaen-17-ylmethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 253170-45-5 2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-3-(1H-indol-3-yl)-propionic acid 2,5,8,11,14,20,23,26,29,32-decaoxa-tricyclo[31.3.1.1^15,19]octatriaconta-1⁽³⁷⁾,15,17,19⁽³⁸⁾,33,35-hexaen-17-ylmethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send