cis-<2-(2)H>-2-(3-Benzyloxypropyl)cyclohexanol

Base Information

• Chemical Name: cis-<2-(2)H>-2-(3-Benzyloxypropyl)cyclohexanol
• CAS No.: 82725-84-6
• Molecular Formula: C₁₆H₂₄O₂
• Molecular Weight: 249.357
• Mol file: 82725-84-6.mol

Synonyms:

Chemical Property of cis-<2-(2)H>-2-(3-Benzyloxypropyl)cyclohexanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-<2-(2)H>-2-(3-Benzyloxypropyl)cyclohexanol

There total 20 articles about cis-<2-(2)H>-2-(3-Benzyloxypropyl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

((3-(cyclohex-1-en-1-yl)propoxy)methyl)benzene (344250-14-2) → trans-<2-(2)H>-2-(3-Benzyloxypropyl)cyclohexanol (82725-84-6,82725-87-9)

Guidance literature:

With sodium hydroxide; lithium aluminium deuteride; boron trifluoride diethyl etherate; dihydrogen peroxide; 1) THF, 2 h, 20 deg C; 2) 60 deg C, 2 h;

Reference yield: 63.0%

C16H21(2)HO2 (344268-52-6) → cis-<2-(2)H>-2-(3-Benzyloxypropyl)cyclohexanol (82725-84-6,82725-87-9)

Guidance literature:

With dihydrogen peroxide; L-Selectride; In tetrahydrofuran; 1) 1 h at -60 deg C and then 12 h at -5 deg C;

Reference yield:

octahydrocoumarin (4430-31-3,14072-79-8,23201-43-6,121902-57-6,121902-58-7) → trans-<2-(2)H>-2-(3-Benzyloxypropyl)cyclohexanol (82725-84-6,82725-87-9)

Guidance literature:

Multi-step reaction with 8 steps

1: 93 percent / LiAlH₄ / diethyl ether / 30 h / Heating

2: pyridine / 4 h / -30 °C

3: KOH / methanol; H₂O / 6 h / Heating

4: 4.5 g / pyridine; benzene / 72 h / Ambient temperature

5: 93 percent / 1,8-Diazabicyclo<5.4.0>undec-7-ene / dioxane / 3 h / Heating

6: 1.8 g / KOH / methanol; H₂O

7: 1.8 g / NaH / tetrahydrofuran / Heating

8: 99 percent / 1) BF₃*Et₂O, LiAlD₄ ; 2) H₂O₂, NaOH / 1) THF, 2 h, 20 deg C; 2) 60 deg C, 2 h

With potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; lithium aluminium deuteride; boron trifluoride diethyl etherate; dihydrogen peroxide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; diethyl ether; water; benzene;

upstream raw materials:

((3-(cyclohex-1-en-1-yl)propoxy)methyl)benzene

octahydrocoumarin

2-(3-hydroxypropyl)cyclohexan-1-ol

3-(cyclohex-1-en-1-yl)propan-1-ol

Downstream raw materials:

C₉H₁₇⁽²⁾HO₂

cis-<2-(2)H>-2-(3-Benzyloxypropyl)cyclohexanol

trans-<2-(2)H>-2-(3-Hydroxypropyl)cyclohexanol

Refernces