1-(2-chlorophenyl)propan-2-amine

Base Information

• Chemical Name: 1-(2-chlorophenyl)propan-2-amine
• CAS No.: 2275-84-5
• Molecular Formula: C₉H₁₂ClN
• Molecular Weight: 169.654

Synonyms:

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Chemical Property of 1-(2-chlorophenyl)propan-2-amine

Chemical Property:

• Vapor Pressure: 0.0307mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-chlorophenyl)propan-2-amine

There total 22 articles about 1-(2-chlorophenyl)propan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.1%

2-Pentanone (107-87-9) + 1-(4-chlorophenyl)propan-2-one (5586-88-9) → (R)‐2‐aminopentane (625-30-9,33985-20-5,54542-13-1,63493-28-7) + (R)-(-)-1-(4'-chloro)phenyl-2-propanamine (2275-84-5)

Guidance literature:

With Candida boidinii formate dehydrogenase; pyridoxal 5'-phosphate; Aspergillus terreus ω-trans aminase; Lysinibacillus fusiformis leucine dehydrogenase; ammonium formate; nicotinamide adenine dinucleotide; In aq. buffer; at 30 ℃; for 24h; pH=8.8; Catalytic behavior; Green chemistry; Enzymatic reaction;

DOI:10.1021/acs.joc.9b02445

Reference yield: 99.1%

1-(4-chlorophenyl)propan-2-one (5586-88-9) → (R)-(-)-1-(4'-chloro)phenyl-2-propanamine (2275-84-5)

Guidance literature:

With Candida boidinii formate dehydrogenase; pyridoxal 5'-phosphate; ammonium formate; nicotinamide adenine dinucleotide; In aq. buffer; at 30 ℃; for 24h; pH=8.8; Green chemistry; Enzymatic reaction;

DOI:10.1021/acs.joc.9b02445

Reference yield: 82.0%

1-chloro-4-(2-nitropropenyl)benzene (710-20-3) → p-Chloroamphetamine (64-12-0,2275-84-5)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 3h; Inert atmosphere; Reflux;

DOI:10.1039/c1ob06251d

upstream raw materials:

1-chloro-4-(2-chloro-propyl)-benzene

formamide

1-(4-chlorophenyl)propan-2-one

1-chloro-4-(2-nitropropenyl)benzene

Downstream raw materials:

N-Methansulfonyl-1-(4-chlorphenyl)-2-aminopropan

1-[2-(4-Chloro-phenyl)-1-methyl-ethyl]-3-methyl-thiourea

Bis-[2-(4-chloro-phenyl)-1-methyl-ethyl]-amine

(S)-(+)-N_.N-Dimethyl-p-chloramphetamin