710-20-3

Upstream product

• 79-24-3 Nitroethane 
• 104-88-1 4-chlorobenzaldehyde 
• 135711-47-6 Butyl-[1-(4-chloro-phenyl)-2-nitro-propyl]-amine 

Downstream Products

• 4231-89-4 [2-bromo-1-(4-chloro-phenyl)-2-nitro-propyl]-methyl ether 
• 101792-33-0 bis-[1-(4-chloro-phenyl)-2-nitro-propyl]-ether 
• 101730-87-4 bis-[2-chloro-1-(4-chloro-phenyl)-2-nitro-propyl]-ether 
• 64-12-0 p-Chloroamphetamine 
• 5586-88-9 1-(4-chlorophenyl)propan-2-one 
• 95838-94-1 5-<(Acetyl)(tert-butoxycarbonyl)methylenamino>-4-(4-chlorphenyl)-4,5-dihydro-2,5-dimethyl-3-furancarbonsaeure-tert-butylester 
• 126760-74-5 ethyl 3-(4-chlorophenyl)-4-methyl-1H-pyrrole-2-carboxylate 
• 1454-65-5 1-(4-chlorophenyl)propan-2-one oxime 
• 95838-91-8 5-<(Acetyl)(methoxycarbonyl)methylenamino>-4-(4-chlorphenyl)-4,5-dihydro-2,5-dimethyl-3-furancarbonsaeure-methylester 
• 135711-47-6 Butyl-[1-(4-chloro-phenyl)-2-nitro-propyl]-amine 
• 921-11-9 2,3,4-pentanetrione 
• 109703-93-7 <4-(4-Chlorphenyl)-2,5-dimethyl-3-pyrrolyl>methylketon 
• 109703-72-2 3-<4-Acetyl-3-(4-chlorphenyl)-2,3-dihydro-2,5-dimethyl-2-furylimino>-2,4-pentandion 
• 4231-90-7 1-(4-Chlor-phenyl)-1-methoxy-2-chlor-2-nitro-propan 

Relevant academic research and scientific papers

A diversity-oriented synthesis of polyheterocycles: Via the cyclocondensation of azomethine imine

Pd-Catalyzed sequential reactions to afford skeletally diverse molecules are described. The reaction involved azomethine imine formation and a cyclocondensation reaction as individual steps. The methodology provides excellent regio- and stereocontrol. Skeletal diversity was ensured by changing the electrophilic counterpart of azomethine imine. Due to its broader diversity and complexity, the DOS methodology is likely to benefit drug discovery and development in the future.

Synthesis of Benzo[4,5]imidazo[2,1-b]thiazole by Copper(II)-Catalyzed Thioamination of Nitroalkene with 1H-Benzo[d]imidazole-2-thiol

A Copper(II)-catalyzed thioamination of β-nitroalkene with 1H-benzo[d]imidazole-2-thiol has been developed for the synthesis of benzo[4,5]imidazo[2,1-b]thiazole derivatives. A variety of N-fused benzoimidazothiazole derivatives are obtained in high yields through successive C?N and C?S bond formations. This protocol is also applicable to β-substituted β-nitroalkenes to afford 2,3-disubstituted benzoimidazothiazoles. (Figure presented.).

Discovery of a PCAF Bromodomain Chemical Probe

The p300/CBP-associated factor (PCAF) and related GCN5 bromodomain-containing lysine acetyl transferases are members of subfamily I of the bromodomain phylogenetic tree. Iterative cycles of rational inhibitor design and biophysical characterization led to the discovery of the triazolopthalazine-based L-45 (dubbed L-Moses) as the first potent, selective, and cell-active PCAF bromodomain (Brd) inhibitor. Synthesis from readily available (1R,2S)-(?)-norephedrine furnished L-45 in enantiopure form. L-45 was shown to disrupt PCAF-Brd histone H3.3 interaction in cells using a nanoBRET assay, and a co-crystal structure of L-45 with the homologous Brd PfGCN5 from Plasmodium falciparum rationalizes the high selectivity for PCAF and GCN5 bromodomains. Compound L-45 shows no observable cytotoxicity in peripheral blood mononuclear cells (PBMC), good cell-permeability, and metabolic stability in human and mouse liver microsomes, supporting its potential for in vivo use.

Iron-catalyzed tandem one-pot addition and cyclization of the blaise reaction intermediate and nitroolefins: Synthesis of substituted NH-pyrroles from nitriles

The iron-catalyzed addition and cyclization of the Blaise reaction intermediate and nitroolefins to synthesize highly functionalized NH-pyrroles in a tandem one-pot manner from nitriles has been developed. This reaction shows good functional group tolerance and affords a broad spectrum of substituted NH-pyrroles in good yields. Copyright

Enzymatic enantiomeric resolution of phenylethylamines structurally related to amphetamine

Both enantiomers of several phenylethylamines, structurally related to amphetamine, have been prepared in good yields and excellent enantiomeric purity by enzymatic kinetic resolution using CAL-B and ethyl methoxyacetate as the acyl donor. In the case of the 4-hydroxyderivative of amphetamine (compound 4i), the S enantiomer racemized possibly in a dynamic kinetic resolution (DKR) under the enzymatic conditions used. The Royal Society of Chemistry 2011.

UV-absorbers for ophthalmic lens materials

UV absorbing monomers that are particularly useful in ophthalmic devices are disclosed.

Ambiphilic dual activation role of a task-specific ionic liquid: 2-hydroxyethylammonium formate as a recyclable promoter and medium for the green synthesis of β-nitrostyrenes

A cost-effective task-specific ionic liquid, 2-hydroxyethylammonium formate, efficiently promotes the condensation of nitroalkanes with various aldehydes to produce β-nitrostyrenes in high to excellent yields at room temperature. This reaction does not involve any hazardous organic solvent and toxic catalyst. The ionic liquid is recovered and recycled for subsequent reactions. In addition, a novel mechanism has been proposed invoking ambiphilic dual activation influence of the ionic liquid.

Spin trapping of alkoxyl radicals generated from 5-methyl and 5-aryl-3-alkoxy-4-methylthiazole-2(3H)-thiones in photochemically induced and microwave-initiated reactions

Methoxyl and isopropoxyl radicals were generated from N-alkoxy-4,5-dimethylthiazole-2(3H)-thiones (λmax～320 nm) and 5-aryl derivatives (aryl=p-XC6H4; X=MeO, H, AcNH, Cl) (λmax～335 nm) in photochemically and microwave-induced reactions. Alkoxyl radicals were trapped with dimethylpyrrolidine N-oxide and characterized as spin adducts via EPR. Cumyloxyl radicals were liberated in a similar manner from N-cumyloxy-5-(4-methoxyphenyl)-4-methylthiazole-2(3H)-thione. A noteworthy bathochromic shift was found for the lowest energy transition of N-(hydroxy)indeno[2,1-d]thiazole-2(3H)-thione (λmax=376 nm), if compared to the UV-vis absorption of N-hydroxy-4-methyl-5-phenylthiazole-2(3H)-thione (λmax=338 nm). Syntheses of alkoxyl radical precursors and procedures for conducting N,O-homolysis are described in a full account.

An efficient solventless synthesis of α-aryl-N-[1-methyl-2-(2/4- chlorophenyl)] ethyl nitrones and their antimicrobial activity

An efficient solventless synthesis of α-aryl-N-[1-methyl-2-(2/4- chlorophenyl)]ethyl nitrones has been achieved in excellent yield. The compounds are characterized by NMR and X-ray studies. The antimicrobial activities of the synthesized compounds have al

2-Benzyl-2-methyl-2H-benzimidazole 1,3-dioxide derivatives: Spectroscopic and theoretical study

The spectroscopic behavior of 2-benzyl-2-methyl-2H-benzimidazole 1,3-dioxide derivatives in solution was studied in terms of electronic and nuclear magnetic resonance (1H and 13C NMR) techniques. The experimental spectra were compared to the theoretical ones, obtained at DFT level, proving that the compounds adopt in solution a bird-like conformational distribution. Also, theoretically this conformational distribution resulted the most stable in gas phase. Infrared spectroscopy was used to study solid state behavior identifying experimentally the N-O stretching near to 1380, 1365 and 1225 cm-1 and the vibrational benzimidazole skeleton near to 1610 and 1590 cm-1. The vibrational spectrum was satisfactorily described by DFT calculations funding the N-O stretching as a coupled vibration near to 1470, 1350 and 1285 cm-1. The fragmentation that takes place in mass spectrometry was assigned for all of the new derivatives.