Technology Process of perseal A
There total 11 articles about perseal A which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 20 ℃;
for 8h;
DOI:10.2478/s11696-010-0040-8
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 24 h / Reflux; Inert atmosphere
2: hydrogenchloride / methanol / 8 h / 20 °C
3: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 20 °C
With
hydrogenchloride; palladium 10% on activated carbon; hydrogen; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol;
1: Mitsunobu reaction;
DOI:10.2478/s11696-010-0040-8
- Guidance literature:
-
Multi-step reaction with 10 steps
1: benzene / 10 h / Reflux
2: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran / 10 h / 0 - 20 °C
3: AD-mix α; methanesulfonamide; water / tert-butyl alcohol / 0 °C
4: pyridine / dichloromethane / 24 h / 0 - 20 °C
5: potassium carbonate / methanol / 5 h / 20 °C
6: pyridinium p-toluenesulfonate / dichloromethane / 10 h / 20 °C
7: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 20 °C
8: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 24 h / Reflux; Inert atmosphere
9: hydrogenchloride / methanol / 8 h / 20 °C
10: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 20 °C
With
pyridine; hydrogenchloride; aluminum (III) chloride; lithium aluminium tetrahydride; methanesulfonamide; AD-mix α; palladium 10% on activated carbon; water; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; dichloromethane; tert-butyl alcohol; benzene;
1: Wittig reaction / 3: Sharpless dihydroxylation / 8: Mitsunobu reaction;
DOI:10.2478/s11696-010-0040-8
