(1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-1-(tetrahydro-2H-pyran-2-yloxy)propan-2-ol

Base Information

Chemical Name:(1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-1-(tetrahydro-2H-pyran-2-yloxy)propan-2-ol
CAS No.:1240326-76-4
Molecular Formula:C₂₂H₂₈O₅
Molecular Weight:372.461
Hs Code.:

Synonyms:(1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-1-(tetrahydro-2H-pyran-2-yloxy)propan-2-ol

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Chemical Property of (1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-1-(tetrahydro-2H-pyran-2-yloxy)propan-2-ol

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Technology Process of (1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-1-(tetrahydro-2H-pyran-2-yloxy)propan-2-ol

There total 10 articles about (1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-1-(tetrahydro-2H-pyran-2-yloxy)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 300678-27-7
(1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-2,3-epoxypropan-1-ol

: 1240326-76-4
(1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-1-(tetrahydro-2H-pyran-2-yloxy)propan-2-ol

Guidance literature:: 3,4-dihydro-2H-pyran; (1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-2,3-epoxypropan-1-ol; With pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃;

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 24h; optical yield given as %de;
DOI:10.3906/kim-0908-201

Reference yield:

: C₂₂H₂₆O₅

: 1240326-76-4
(1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-1-(tetrahydro-2H-pyran-2-yloxy)propan-2-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 24h; optical yield given as %ee;
DOI:10.2478/s11696-010-0040-8

Reference yield:

: 38157-08-3
(E)-3-(4-benzyloxy-3-methoxyphenyl)acrylic acid ethyl ester

: 1240326-76-4
(1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-1-(tetrahydro-2H-pyran-2-yloxy)propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran

2.1: ; methanesulfonamide; water; tert-butyl alcohol / 0 °C

3.1: pyridine / dichloromethane / 20 °C

4.1: potassium carbonate / methanol / 20 °C

5.1: pyridinium p-toluenesulfonate / dichloromethane

5.2: 20 °C

With pyridine; aluminum (III) chloride; lithium aluminium tetrahydride; methanesulfonamide; water; pyridinium p-toluenesulfonate; potassium carbonate; tert-butyl alcohol; In tetrahydrofuran; methanol; dichloromethane; 2.1: Sharpless dihydroxylation;
DOI:10.1016/j.mencom.2010.05.009