Butanamide, N-cyclohexyl-N-methyl-4-[(1,2,3,4-tetrahydro-2-oxo-6-quinazolinyl)oxy]-

Base Information

Chemical Name:Butanamide, N-cyclohexyl-N-methyl-4-[(1,2,3,4-tetrahydro-2-oxo-6-quinazolinyl)oxy]-
CAS No.:105763-56-2
Molecular Formula:C19H27N3O3
Molecular Weight:345.442
Hs Code.:
Mol file:105763-56-2.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Butanamide, N-cyclohexyl-N-methyl-4-[(1,2,3,4-tetrahydro-2-oxo-6-quinazolinyl)oxy]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Butanamide, N-cyclohexyl-N-methyl-4-[(1,2,3,4-tetrahydro-2-oxo-6-quinazolinyl)oxy]-

There total 12 articles about Butanamide, N-cyclohexyl-N-methyl-4-[(1,2,3,4-tetrahydro-2-oxo-6-quinazolinyl)oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 105763-55-1
{2-Amino-5-[3-(cyclohexyl-methyl-carbamoyl)-propoxy]-benzyl}-carbamic acid phenyl ester

: 105763-56-2
N-cyclohexyl-N-methyl-4-[(3,4-dihydro-2-oxo-1H-quinazolin-6-yl)oxy]butyramide

Guidance literature:: In N,N-dimethyl-formamide; at 110 ℃; for 0.5h;
DOI:10.1021/jm00385a011

Reference yield:

: 100-60-7
N-methylcyclohexylamine

: 105763-56-2
N-cyclohexyl-N-methyl-4-[(3,4-dihydro-2-oxo-1H-quinazolin-6-yl)oxy]butyramide

Guidance literature:: Multi-step reaction with 8 steps

1: aq. Na₂CO₃ / tetrahydrofuran / 1 h / Ambient temperature

2: 100 percent / NaBH₄ / ethanol / 1 h / Ambient temperature

3: Me₂N=CHBr⁽¹⁺⁾*Br^(1-) / dioxane / 0.5 h / Heating

4: 54 percent / dimethylformamide / 100 °C

5: H₂NNH₂ / ethanol / 0.5 h / Heating

6: aq. Na₂CO₃ / tetrahydrofuran / 0.5 h / Ambient temperature

7: H₂ / 10percent Pd/C / ethanol / 2585.7 Torr

8: 90 percent / dimethylformamide / 0.5 h / 110 °C

With sodium tetrahydroborate; hydrogen; sodium carbonate; N-(bromomethylene)-N-methylmethanaminium bromide; hydrazine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00385a011

Reference yield:

: 42454-06-8
2-nitro-5-hydroxybenzaldehyde

: 105763-56-2
N-cyclohexyl-N-methyl-4-[(3,4-dihydro-2-oxo-1H-quinazolin-6-yl)oxy]butyramide

Guidance literature:: Multi-step reaction with 11 steps

1: 95 percent / K₂CO₃ / dimethylformamide / 1 h / 100 °C

2: 96 percent / aq. KOH / ethanol

3: oxalyl chloride / benzene; dimethylformamide / 1 h / Ambient temperature

4: aq. Na₂CO₃ / tetrahydrofuran / 1 h / Ambient temperature

5: 100 percent / NaBH₄ / ethanol / 1 h / Ambient temperature

6: Me₂N=CHBr⁽¹⁺⁾*Br^(1-) / dioxane / 0.5 h / Heating

7: 54 percent / dimethylformamide / 100 °C

8: H₂NNH₂ / ethanol / 0.5 h / Heating

9: aq. Na₂CO₃ / tetrahydrofuran / 0.5 h / Ambient temperature

10: H₂ / 10percent Pd/C / ethanol / 2585.7 Torr

11: 90 percent / dimethylformamide / 0.5 h / 110 °C

With potassium hydroxide; sodium tetrahydroborate; oxalyl dichloride; hydrogen; sodium carbonate; N-(bromomethylene)-N-methylmethanaminium bromide; potassium carbonate; hydrazine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00385a011