C₂₆H₃₀N₂O₅

Base Information

• Chemical Name: C₂₆H₃₀N₂O₅
• CAS No.: 1208246-04-1
• Molecular Formula: C₂₆H₃₀N₂O₅
• Molecular Weight: 450.535
• Mol file: 1208246-04-1.mol

Synonyms:

Chemical Property of C₂₆H₃₀N₂O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₃₀N₂O₅

There total 3 articles about C₂₆H₃₀N₂O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethylethyl [(1S)-2-(4-bromophenyl)-1-(hydroxymethyl)ethyl]carbamate (854760-84-2) → C26H30N2O5 (1208246-04-1)

Guidance literature:

Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Large scale reaction

2: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 5 h / Reflux; Large scale reaction

With bis-triphenylphosphine-palladium(II) chloride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; 1: Mitsunobu reaction / 2: Stille coupling;

DOI:10.1021/op100186c

Reference yield:

4-bromo-N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-phenylalanine (62129-39-9,79561-82-3) → C26H30N2O5 (1208246-04-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 - 20 °C / Large scale reaction

1.2: 0 - 15 °C / Large scale reaction

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Large scale reaction

3.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 5 h / Reflux; Large scale reaction

With bis-triphenylphosphine-palladium(II) chloride; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; 2.1: Mitsunobu reaction / 3.1: Stille coupling;

DOI:10.1021/op100186c

Reference yield:

1,1-dimethylethyl {(1S)-2-(4-bromophenyl)-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]ethyl}carbamate (869567-96-4) + tributyl(1-ethoxyvinyl)stannane (97674-02-7) → C26H30N2O5 (1208246-04-1)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; for 5h; Reflux; Large scale reaction;

DOI:10.1021/op100186c

upstream raw materials:

1,1-dimethylethyl [(1S)-2-(4-bromophenyl)-1-(hydroxymethyl)ethyl]carbamate

1,1-dimethylethyl {(1S)-2-(4-bromophenyl)-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]ethyl}carbamate

tributyl(1-ethoxyvinyl)stannane

4-bromo-N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-phenylalanine

Downstream raw materials:

3-chloro-N-{(1S)-2-[(N,N-dimethylglycyl)amino]-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide

1,1-dimethylethyl {(1S)-2-[4-(bromoacetyl)phenyl]-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]ethyl}carbamate

3-chloro-N-{(1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide

C₂₈H₃₁ClN₄O₃