C₃₃H₄₈O₅Si

Base Information

• Chemical Name: C₃₃H₄₈O₅Si
• CAS No.: 1359984-34-1
• Molecular Formula: C₃₃H₄₈O₅Si
• Molecular Weight: 552.827
• Mol file: 1359984-34-1.mol

Synonyms:

Chemical Property of C₃₃H₄₈O₅Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₃H₄₈O₅Si

There total 10 articles about C₃₃H₄₈O₅Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(R,E)-1-((4S,5S)-5-((R)-1-(tert-butyldiphenylsilyloxy)butyl)-2,2-dimethyl-1,3-dioxolan-4-yl)hexa-1,5-dien-3-ol (1359984-33-0) + chloromethyl methyl ether (107-30-2) → C33H48O5Si (1359984-34-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; at 20 ℃; for 12h;

DOI:10.1016/j.tetlet.2011.12.119

Reference yield:

(R,Z)-ethyl 4-(tert-butyldiphenylsilyloxy)hept-2-enoate (1359984-28-3) → C33H48O5Si (1359984-34-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: AD-mix β; methanesulfonamide; water / tert-butyl alcohol / 24 h / 20 °C

2.1: CSA

3.1: diisobutylaluminium hydride / dichloromethane / -78 °C

4.1: lithium hexamethyldisilazane / 1 h / 0 °C

5.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 6 h / Reflux

6.1: titanium(IV) isopropylate; (R)-1,1'-Bi-2-naphthol / dichloromethane / 0.17 h / Molecular sieve

6.2: 80.17 h / -78 - -20 °C

6.3: 1 h

7.1: N-ethyl-N,N-diisopropylamine / 12 h / 20 °C

With titanium(IV) isopropylate; Hoveyda-Grubbs catalyst second generation; methanesulfonamide; AD-mix β; water; (R)-1,1'-Bi-2-naphthol; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In dichloromethane; tert-butyl alcohol; 1.1: Sharpless dihydroxylation / 4.1: Wittig reaction / 6.1: Keck allylation / 6.2: Keck allylation;

DOI:10.1016/j.tetlet.2011.12.119

Reference yield:

(2R,3S,4R)-ethyl 4-(tert-butyldiphenylsilyloxy)-2,3-dihydroxyheptanoate (1359984-30-7) → C33H48O5Si (1359984-34-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: CSA

2.1: diisobutylaluminium hydride / dichloromethane / -78 °C

3.1: lithium hexamethyldisilazane / 1 h / 0 °C

4.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 6 h / Reflux

5.1: titanium(IV) isopropylate; (R)-1,1'-Bi-2-naphthol / dichloromethane / 0.17 h / Molecular sieve

5.2: 80.17 h / -78 - -20 °C

5.3: 1 h

6.1: N-ethyl-N,N-diisopropylamine / 12 h / 20 °C

With titanium(IV) isopropylate; Hoveyda-Grubbs catalyst second generation; (R)-1,1'-Bi-2-naphthol; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In dichloromethane; 3.1: Wittig reaction / 5.1: Keck allylation / 5.2: Keck allylation;

DOI:10.1016/j.tetlet.2011.12.119

upstream raw materials:

(R,Z)-ethyl 4-(tert-butyldiphenylsilyloxy)hept-2-enoate

(2R,3S,4R)-ethyl 4-(tert-butyldiphenylsilyloxy)-2,3-dihydroxyheptanoate

C₂₈H₄₀O₅Si

C₂₆H₃₆O₄Si

Downstream raw materials:

C₃₃H₅₀O₆Si

C₃₃H₄₈O₇Si

Refernces