NH-(PEG4-t-butyl ester)2

Base Information

Chemical Name:NH-(PEG4-t-butyl ester)2
CAS No.:2055041-41-1
Molecular Formula:C₃₀H₅₉NO₁₂
Molecular Weight:625.798
Hs Code.:
Mol file:2055041-41-1.mol

Synonyms:

Suppliers and Price of NH-(PEG4-t-butyl ester)2

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

BroadPharm
NH-bis(PEG4-t-butylester) 98%
1 G
$ 950.00

Activate Scientific
HN-(PEG4-CH2CH2COOtBu)2 97%
1 g
$ 869.00

Acrotein
HN-(PEG4-CH2CH2COOtBu)2 97%
1g
$ 605.00

Acrotein
HN-(PEG4-CH2CH2COOtBu)2 97%
0.25g
$ 265.83

Total 8 raw suppliers

Chemical Property of NH-(PEG4-t-butyl ester)2

Chemical Property:

Boiling Point:625.8±50.0 °C(Predicted)
PKA:8.39±0.19(Predicted)
Density:1.059±0.06 g/cm3(Predicted)
Solubility.:Soluble in Water, DMSO, DCM, DMF

Purity/Quality:

97% ^*data from raw suppliers

NH-bis(PEG4-t-butylester) 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description NH-bis(PEG4-t-butyl ester) is a very useful PEG reagent containing an amino group with two t-butyl esters. The amino groups is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), t-butyl protected carboxyl group can be deprotected under acidic conditions.

Technology Process of NH-(PEG4-t-butyl ester)2

There total 10 articles about NH-(PEG4-t-butyl ester)2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 581066-04-8
tert-butyl 1-azido-3,6,9,12-tetraoxapentadecan-15-oate

: 2055041-41-1
di-tert-butyl 4,7,10,13,19,22,25,28-octaoxa-16-azahentriacontane-1,31-dioate

Guidance literature:: With palladium on activated charcoal; hydrogen; In 1,4-dioxane; at 60 ℃; for 4h;
DOI:10.1039/C8OB02097C

Reference yield:

: 581066-04-8
tert-butyl 1-azido-3,6,9,12-tetraoxapentadecan-15-oate

: 581065-95-4,872340-65-3
tert-butyl 3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]propanoate

: 2055041-41-1
di-tert-butyl 4,7,10,13,19,22,25,28-octaoxa-16-azahentriacontane-1,31-dioate

Guidance literature:: With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; Solvent; Temperature;
DOI:10.1039/C8OB02097C

Reference yield:

: 112-60-7
Tetraethylene glycol

: 2055041-41-1
di-tert-butyl 4,7,10,13,19,22,25,28-octaoxa-16-azahentriacontane-1,31-dioate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium iodide; silver(l) oxide / dichloromethane / 0 - 20 °C / Inert atmosphere

2: sodium azide / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

3: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: palladium on activated charcoal; hydrogen / 1,4-dioxane / 4 h / 60 °C

With sodium azide; palladium on activated charcoal; potassium tert-butylate; hydrogen; potassium iodide; silver(l) oxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/C8OB02097C