C₁₂H₁₀N₄O₂

Base Information

• Chemical Name: C₁₂H₁₀N₄O₂
• CAS No.: 1419746-20-5
• Molecular Formula: C₁₂H₁₀N₄O₂
• Molecular Weight: 242.237
• Mol file: 1419746-20-5.mol

Synonyms:

Chemical Property of C₁₂H₁₀N₄O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₀N₄O₂

There total 2 articles about C₁₂H₁₀N₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (1220219-22-6) + 2-amino-6-chloro-4-pyrimidinol (1194-21-4) → C12H10N4O2 (1419746-20-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In N,N-dimethyl-formamide; at 140 ℃; Microwave irradiation;

DOI:10.1016/j.bmcl.2012.11.057

Reference yield:

5-bromo-2-methoxybenzonitrile (144649-99-0) → C12H10N4O2 (1419746-20-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 8 h / 120 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 140 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide; 1: |Miyaura Borylation Reaction / 2: |Suzuki-Miyaura Coupling;

DOI:10.1016/j.bmcl.2012.11.057

upstream raw materials:

5-bromo-2-methoxybenzonitrile

2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

2-amino-6-chloro-4-pyrimidinol