Carbamic acid, (hydroxymethyl)-, 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester

Base Information

Chemical Name:Carbamic acid, (hydroxymethyl)-, 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester
CAS No.:18999-70-7
Deprecated CAS:52208-00-1
Molecular Formula:C₁₂H₁₅NO₄
Molecular Weight:237.255
Hs Code.:
DSSTox Substance ID:DTXSID30172441
Nikkaji Number:J855.468D
Wikidata:Q83042542

Synonyms:N-Hydroxymethylcarbofuran;BRN 1380621;CARBAMIC ACID, (HYDROXYMETHYL)-, 2,3-DIHYDRO-2,2-DIMETHYL-7-BENZOFURANYL ESTER;(Hydroxymethyl)carbamic acid 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester;18999-70-7;DTXSID30172441;LS-49941;N-(Hydroxymethyl)carbamic acid (2,2-dimethyl-2,3-dihydrobenzofuran)-7-yl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, (hydroxymethyl)-, 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester

Chemical Property:

Vapor Pressure:6.11E-06mmHg at 25°C
XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:237.10010796
Heavy Atom Count:17
Complexity:292

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(CC2=C(O1)C(=CC=C2)OC(=O)NCO)C

Technology Process of Carbamic acid, (hydroxymethyl)-, 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester

There total 4 articles about Carbamic acid, (hydroxymethyl)-, 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 222641-43-2
benzyloxymethylcarbamic acid 2,2-dimethyl-2,3-dihydrobenzofuran-7-yl ester

: 18999-70-7,52208-00-1
hydroxymethylcarbamic acid 2,2-dimethyl-2,3-dihydrobenzofuran-7-yl ester

Guidance literature:: With trimethylsilyl iodide; In tetrachloromethane; for 1h;
DOI:10.1021/jf980347+

Reference yield:

: 1563-38-8
2,3-dihydro-2,2-dimethylbenzofuran-7-ol

: 18999-70-7,52208-00-1
hydroxymethylcarbamic acid 2,2-dimethyl-2,3-dihydrobenzofuran-7-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / Et₃N / benzene / 18 h / Heating

2: 50 percent / Me₃SiI / CCl₄ / 1 h

With trimethylsilyl iodide; triethylamine; In tetrachloromethane; benzene;
DOI:10.1021/jf980347+

Reference yield:

: 1563-66-2
2,3-dihydro-2,2-dimethyl-7-benzofuranol methylcarbamate

: 18999-70-7,52208-00-1
hydroxymethylcarbamic acid 2,2-dimethyl-2,3-dihydrobenzofuran-7-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / KOH / ethanol

2: 66 percent / Et₃N / benzene / 18 h / Heating

3: 50 percent / Me₃SiI / CCl₄ / 1 h

With potassium hydroxide; trimethylsilyl iodide; triethylamine; In tetrachloromethane; ethanol; benzene;
DOI:10.1021/jf980347+