Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-benzyl) ester O'-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl) ester

Base Information

• Chemical Name: Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-benzyl) ester O'-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl) ester
• CAS No.: 130674-93-0
• Molecular Formula: C₄₅H₄₁ClN₅O₉PS₂
• Molecular Weight: 926.407
• Mol file: 130674-93-0.mol

Synonyms:

Chemical Property of Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-benzyl) ester O'-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-benzyl) ester O'-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl) ester

There total 2 articles about Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-benzyl) ester O'-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

S-4-Chlorobenzyl dithiophosphorodichloridate (130659-69-7) → Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-benzyl) ester O'-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl) ester (130674-93-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dioxane / 1 h

2: dioxane / 0.33 h / Ambient temperature

With pyridine; In 1,4-dioxane;

DOI:10.1016/S0040-4039(00)97430-6

Reference yield:

O,O-Bis-(3,4-dihydro-4-oxobenzotriazin-3-yl) S-4-chlorobenzyl dithiophosphate (130659-72-2) + 5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-benzyl) ester O'-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl) ester (130674-93-0)

Guidance literature:

In 1,4-dioxane; for 0.333333h; Ambient temperature;

DOI:10.1016/S0040-4039(00)97430-6

Reference yield:

Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-benzyl) ester O'-(4-oxo-4H-benzo[d][1,2,3]triazin-3-yl) ester (130674-93-0) → C38H37ClN2O8PS2(1-)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dioxane / 0.75 h / Ambient temperature

2: H₂NCO(NC)C=C(S^-)2 / dimethylformamide / 26 °C / or with PhSH, Et₃N, dioxane

With pyridine; 2-carbamoyl-2-cyanoethylene-1,1-dithiolate; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)97430-6

upstream raw materials:

O,O-Bis-(3,4-dihydro-4-oxobenzotriazin-3-yl) S-4-chlorobenzyl dithiophosphate

5'-O-(4-4'-dimethoxytrityl)thymidine

S-4-Chlorobenzyl dithiophosphorodichloridate

Downstream raw materials:

O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> S-(4-chlorobenzyl) O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate