2,3,5-trimethoxyphenylacetonitrile

Base Information

• Chemical Name: 2,3,5-trimethoxyphenylacetonitrile
• CAS No.: 146202-78-0
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.229
• Mol file: 146202-78-0.mol

Synonyms:

Chemical Property of 2,3,5-trimethoxyphenylacetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,5-trimethoxyphenylacetonitrile

There total 6 articles about 2,3,5-trimethoxyphenylacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-3,5,6-trimethoxyphenylacetonitrile (146202-75-7) → 2,3,5-trimethoxyphenylacetonitrile (146202-78-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

Reference yield:

2,3,5-trimethoxy-benzyl alcohol (107301-77-9) → 2,3,5-trimethoxyphenylacetonitrile (146202-78-0)

Guidance literature:

With pyridine; thionyl chloride; diethyl ether; Erwaermen des Reaktionsprodukts mit NaCN in wss. Aethanol;

DOI:10.1021/ja01629a061

Reference yield:

2,3,5-trimethoxy-benzaldehyde (5556-84-3) → 2,3,5-trimethoxyphenylacetonitrile (146202-78-0)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄

2: SOCl₂; pyridine; diethyl ether / Erwaermen des Reaktionsprodukts mit NaCN in wss. Aethanol

With pyridine; lithium aluminium tetrahydride; thionyl chloride; diethyl ether;

DOI:10.1021/ja01629a061

upstream raw materials:

2,3,5-trimethoxy-benzyl alcohol

2-bromo-3,5,6-trimethoxyphenylacetonitrile

1,2,5-trimethoxy-3-methylbenzene

Formic acid 2,4-dimethoxy-6-methyl-phenyl ester