Technology Process of 3-methyl-3-(1-phenylvinyl)cyclopentanone
There total 1 articles about 3-methyl-3-(1-phenylvinyl)cyclopentanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-bromovinylbenzene;
With
iodine; magnesium;
In
tetrahydrofuran;
at 70 ℃;
Inert atmosphere;
With
copper(l) iodide;
In
tetrahydrofuran;
at -41 ℃;
for 0.5h;
Inert atmosphere;
3-Methyl-2-cyclopenten-1-one;
In
tetrahydrofuran;
at -41 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/jo400139g
- Guidance literature:
-
cyclopropyltriphenylphosphonium bromide;
With
sodium hydride;
In
tetrahydrofuran;
at 62 ℃;
for 18h;
Schlenk technique;
Inert atmosphere;
3-methyl-3-(1-phenylvinyl)cyclopentanone;
With
Tris(3,6-dioxaheptyl)amine;
In
tetrahydrofuran;
at 62 ℃;
for 8.5h;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/jo400139g
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran / 18 h / 62 °C / Schlenk technique; Inert atmosphere
1.2: 8.5 h / 62 °C / Schlenk technique; Inert atmosphere
2.1: silver(I) hexafluorophosphate / dichloromethane / 4 h
With
silver(I) hexafluorophosphate; sodium hydride;
In
tetrahydrofuran; dichloromethane;
1.1: |Wittig Olefination / 1.2: |Wittig Olefination;
DOI:10.1021/jo400139g
